Vani Nilakantan

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Favorable balance of anti-oxidant/pro-oxidant systems and ablated oxidative stress in Brown Norway rats in renal ischemia-reperfusion injury

Vani Nilakantan, Gail Hilton, +4 authors Brian D. Shames
Molecular and Cellular Biochemistry
2007

Oxidative stress is important in the pathogenesis of renal ischemia-reperfusion (IR) injury; however whether imbalances in reactive oxygen production and disposal account for susceptibility to injury… (More)

Oxidant-mediated apoptosis in proximal tubular epithelial cells following ATP depletion and recovery.

Cheryl J. Maenpaa, Brian D. Shames, Scott K. Van Why, Christopher Peter Johnson, Vani Nilakantan
Free radical biology & medicine
2008

Oxidant-mediated apoptosis has been implicated in renal injury due to ischemia reperfusion (IR); however, the apoptotic signaling pathways following IR have been incompletely defined. The purpose of… (More)

Liver-specific catalase expression in transgenic mice inhibits NF-kappaB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate.

Vani Nilakantan, B. Spear, Howard Perry Glauert
Carcinogenesis
1998

Peroxisome proliferators are a group of non-genotoxic hepatic carcinogens that have been proposed to act by increasing oxidative damage in the liver. To test this hypothesis, we have examined if… (More)

Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3.

Bernadette P Cabigas, Jidong Su, +7 authors John E Baker
Cardiovascular research
2006

OBJECTIVE The relative contributions of the fraction of inspired oxygen (FIO2) and atmospheric pressure (ATM) to cardioprotection are unknown. We determined whether the product of FIO2 x ATM (oxygen… (More)

MnTMPyP, a cell-permeant SOD mimetic, reduces oxidative stress and apoptosis following renal ischemia-reperfusion.

Huan Ling Liang, Gail Hilton, Jordan Mortensen, Kevin R. Regner, Christopher Peter Johnson, Vani Nilakantan
American journal of physiology. Renal physiology
2009

Oxidative stress and apoptosis are important factors in the etiology of renal ischemia-reperfusion (I/R) injury. The present study tested the hypothesis that the cell-permeant SOD mimetic… (More)

SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery.

Huan Ling Liang, Filip Sedlic, Zeljko J Bosnjak, Vani Nilakantan
Free radical biology & medicine
2010

Generation of excessive reactive oxygen species (ROS) leads to mitochondrial dysfunction, apoptosis, and necrosis in renal ischemia-reperfusion (IR) injury. Previously we showed that lentiviral… (More)

Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells

Huan Ling Liang, Jody R Arsenault, Jordan Mortensen, Frank Park, Christopher Peter Johnson, Vani Nilakantan
Apoptosis
2009

Reactive oxygen species (ROS) contribute significantly to apoptosis in renal ischemia-reperfusion (IR) injury, however the exact mechanisms are not well understood. We used novel lentiviral vectors… (More)

Post-translational modification of manganese superoxide dismutase in acutely rejecting cardiac transplants : Role of inducible nitric oxide synthase

Vani Nilakantan, Nadine L. N. Halligan, +7 authors Galen M. Pieper
The Journal of heart and lung transplantation…
2005

BACKGROUND Nitration of a critical tyrosine residue in the active site of manganese superoxide dismutase (MnSOD) can lead to enzyme inactivation. In this study, we examined the effect of inducible… (More)

20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells.

Vani Nilakantan, Cheryl J. Maenpaa, Guangfu Jia, Richard J. Roman, Frank Park
American journal of physiology. Renal physiology
2008

20-HETE, a metabolite of arachidonic acid, has been implicated as a mediator of free radical formation and tissue death following ischemia-reperfusion (IR) injury in the brain and heart. The present… (More)

Prediction and detection models for acute kidney injury in hospitalized older adults

Rohit J. Kate, Ruth M. Perez, Debesh Mazumdar, Kalyan S. Pasupathy, Vani Nilakantan
BMC Med. Inf. & Decision Making
2016

BACKGROUND Acute Kidney Injury (AKI) occurs in at least 5 % of hospitalized patients and can result in 40-70 % morbidity and mortality. Even following recovery, many subjects may experience… (More)

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