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Developmental dyslexics often complain that small letters appear to blur and move around when they are trying to read. Anatomical, electrophysiological, psychophysical and brain-imaging studies have all contributed to elucidating the functional organization of these and other visual confusions. They emerge not from damage to a single visual relay but from(More)
Normal vision in Drosophila requires NINAC, a class III myosin. Class III myosins are hybrid motor-signaling molecules, with an N-terminal kinase domain, highly conserved head and neck domains, and a class III-specific tail domain. In Drosophila rhabdomeres, NINAC interacts with actin filaments and with a PDZ scaffolding protein to organize the(More)
Complete gene knockouts are highly informative about gene function. We exome sequenced 3,222 British Pakistani­heritage adults with high parental relatedness, discovering 1,111 rare­variant homozygous likely loss of function (rhLOF) genotypes predicted to disrupt (knockout) 781 genes.​ ​ Based on depletion of rhLOF genotypes, we estimate that 13.6% of(More)
Space and time are intimately coupled dimensions in the human brain. Several lines of evidence suggest that space and time are processed by a shared analogue magnitude system. It has been proposed that actions are instrumental in establishing this shared magnitude system. Here we provide evidence in support of this hypothesis, by showing that the(More)
Neuropsychological deficits of memory and spatial perception have been associated with substance abuse. The present study assessed the degree to which verbal abstraction is impaired in substance abusers because this function typically is reduced in diffuse cerebral disorders. Test scores of 100 consecutively admitted substance-abusing patients indicated(More)
Eye tracking abnormalities have been proposed as a trait marker for schizophrenia on the basis of their familial prevalence and the consistency of tracking over time in clinically stable patients. However, few studies have examined stability through acute episodes of illness, and most studies have not analyzed changes in different forms of eye movements.(More)
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