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Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival.
Brucella abortus, a mammalian pathogen, and Rhizobium meliloti, a phylogenetically related plant symbiont, establish chronic infections in their respective hosts. Here a highly conserved B. abortusExpand
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Cytokine Response to Infection with Bacillus anthracis Spores
ABSTRACT Bacillus anthracis, the etiological agent of anthrax, is a gram-positive, spore-forming bacterium. The inhalational form of anthrax is the most severe and is associated with rapidExpand
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Murine Aerosol Challenge Model of Anthrax
ABSTRACT The availability of relevant and useful animal models is critical for progress in the development of effective vaccines and therapeutics. The infection of rabbits and non-human primates withExpand
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MyD88-Dependent Signaling Contributes to Protection following Bacillus anthracis Spore Challenge of Mice: Implications for Toll-Like Receptor Signaling
ABSTRACT Bacillus anthracis is a spore-forming, gram-positive organism that is the causative agent of the disease anthrax. Recognition of Bacillus anthracis by the host innate immune system likelyExpand
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The Brucella abortus Cu,Zn Superoxide Dismutase Is Required for Optimal Resistance to Oxidative Killing by Murine Macrophages and Wild-Type Virulence in Experimentally Infected Mice
ABSTRACT Two-dimensional gel electrophoretic analysis of cell lysates from Brucella abortus 2308 and the isogenic hfq mutant Hfq3 revealed that the RNA binding protein Hfq (also known as host factorExpand
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Complement Depletion Renders C57BL/6 Mice Sensitive to the Bacillus anthracis Sterne Strain
ABSTRACT Concerns regarding safety and control of virulent Bacillus anthracis have created substantial hurdles to the study of anthrax. The Sterne strain is considered relatively safe to study, butExpand
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Systemic but not mucosal immunity induced by AVA prevents inhalational anthrax.
Improved vaccines and adjuvants are being developed to reduce the threat posed by a terrorist attack involving aerosolized anthrax spores. Nevertheless, uncertainty persists concerning the relativeExpand
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Activation of the vrg6 promoter of Bordetella pertussis by RisA.
The BvgAS two-component system positively regulates the expression of the virulence genes of Bordetella pertussis and negatively regulates a second set of genes whose function is unknown. TheExpand
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Role of catalase in the virulence of Brucella melitensis in pregnant goats.
An isogenic katE mutant derived from virulent Brucella melitensis 16M displays hypersensitivity to hydrogen peroxide in disk sensitivity assays but retains the capacity to colonize pregnant goats andExpand
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Analysis of bvgR expression in Bordetella pertussis.
Bordetella pertussis, the causative agent of whooping cough, produces a wide array of factors that are associated with its ability to cause disease. The expression and regulation of these virulenceExpand
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