Vanessa Heinrich

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The efficacy of radiotherapy is limited by the response of normal tissues within the radiation field. The application of normal-tissue-specific radioprotectors may improve the therapeutic benefit of radiotherapy. The purpose of the present study was to explore the in vivo normal-tissue radioprotective potential of Bowman-Birk proteinase inhibitor (BBI),(More)
Repeat radiation is a rarely used treatment strategy that must be performed with caution. The efficacy and toxicity of a second curative radiotherapy series was investigated in cases of recurrent breast cancer. Forty-two patients treated from 1993 to 2003 with resection (n = 30) and postoperative re-irradiation or definitive re-irradiation (n = 12) for(More)
Radiotherapy has become an effective treatment in the management of melanoma patients. It has its place beneath surgical treatment options in a tumor entity that has only limited response to systemic medical therapies. New therapies, such as ipilimumab and vemurafenib, may prolong survival for several months but will cure only a few patients. Radiotherapy(More)
BACKGROUND Current studies on salvage radiotherapy (sRT) investigate timing, dose-escalation and anti-hormonal treatment (ADT) for recurrent prostate cancer. These approaches could either be limited by radiation-related susceptibility of the anastomosis or by suspected side-effects of long-term ADT. A phase II protocol was developed to investigate the(More)
Die Anwendung von lokalen und regionalen Hyperthermietechniken während einer Radio- bzw. Radiochemotherapie kann klinische Endpunkte wie z. B. die Ansprechrate, die lokale Kontrolle und das Gesamtüberleben signifikant verbessern. Etliche randomisierte Studien haben den zusätzlichen Nutzen einer Hyperthermie insbesondere beim lokal rezidivierten(More)
PURPOSE The aim of this study was to evaluate the impact of deep regional hyperthermia on long-term local control and survival in locally advanced non-metastatic rectal cancer. METHODS In total 103 patients with locally advanced non-metastatic rectal cancer were treated preoperatively with either neoadjuvant radiochemotherapy alone (n = 43) or the same(More)
Doses of 0.5 mg/kg body weight, 1.5 mg/kg, 3.0 mg/kg, 7.5 mg/kg, and 15.0 mg/kg of phenylmercury acetate (PMA), as a model substance, were administered to Ico:WIST rats, over periods of 1, 5, 20, and 40 days, for the purpose of studying time-dependent and dose-related buildup of adaptive alterations in kidney. Substance-related damage to kidneys was(More)