Vanessa E Van Doren

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Schizophrenia is a heritable brain illness with unknown pathogenic mechanisms. Schizophrenia's strongest genetic association at a population level involves variation in the major histocompatibility complex (MHC) locus, but the genes and molecular mechanisms accounting for this have been challenging to identify. Here we show that this association arises in(More)
Like humans, hamadryas baboons (Papio hamadryas) are unusual among primates in having a multilevel social system and stable pair bonds, and are thus a useful model for the evolution of human sociality. While the kinship structure and sex-biased dispersal patterns that underlie human social organization have been extensively elucidated, the impact of these(More)
PURPOSE Dihydrotestosterone (DHT) is an important factor in prostate cancer (PCA) genesis and disease progression. Given PCA's strong genetic component, we evaluated the possibility that variation in genes involved in DHT metabolism influence PCA risk. EXPERIMENTAL DESIGN We investigated copy number variants (CNV) and single nucleotide polymorphisms(More)
Comparisons were made of the Young's moduli obtained with tests that impose static, low-frequency, or high-frequency elastic deformations on dental composite systems. The frequency of the imposed stress was reflected in the absolute value of Young's modulus. However, the values obtained at different test frequencies could be compared and understood by(More)
Thousands of genomic segments appear to be present in widely varying copy numbers in different human genomes. We developed ways to use increasingly abundant whole-genome sequence data to identify the copy numbers, alleles and haplotypes present at most large multiallelic CNVs (mCNVs). We analyzed 849 genomes sequenced by the 1000 Genomes Project to identify(More)
Several mechanical properties of experimental composites and an unfilled resin were studied. The dynamic Young's modulus was measured with a non-destructive dynamic method. The Young's modulus and also the transverse strength were determined statically by means of three-point bending. The hardness was studied by means of Wallace indentation depth(More)
The non-destructive determination of Young's modulus of dental composites by means of the fundamental period was found to be reliable and accurate. Post-polymerization effects could clearly be detected. Exponential regression analysis showed a correlation coefficient of 0.92, after logarithmic transformation, with volumetric filler content. The high(More)
The effect of pressure and temperature on the vibrational spectra of hydrogen bonded systems has been studied on amides, thioamides, carboxylic acids and urea. The compounds under investigation are indicative for the kind of hydrogen bonding changing from pure intermolecular to intramolecular and dimeric forms. The discussion of the temperature dependence(More)
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