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International seminar on the red blood cells as vehicles for drugs
- Y. Godfrin, F. Horand, +10 authors K. Gunter
- Expert opinion on biological therapy
- 1 January 2012
The aim is to provide an overview of the applications, particularly for clinical use, of this innovative formulation of L-asparaginase-loaded RBCs, one of the most promising drug delivery systems investigated in recent decades. Expand
Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRα and β
Abstract A series of branched and unbranched anilinohexafluoroisopropanols related to the known sulfonamide T0901317 were prepared and evaluated as activators/modulators of both LXRα and LXRβ. A… Expand
Effect of inositol hexaphosphate–loaded red blood cells (RBCs) on the rheology of sickle RBCs
The recent in vitro demonstration that inositol hexaphosphate–loaded red blood cells (IHP‐RBCs) may reduce the risks of sickling of sickle RBCs exposed to hypoxia make them potentially useful in transfused sickle cell anemia (SCA) patients. Expand
Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.
A series of branched and unbranched anilinohexafluoroisopropanols related to the known sulfonamide T0901317 were prepared and evaluated as activators/modulators of both LXRalpha and LXRbeta, suggesting that this series may yield candidates with improved efficacy/safety profiles compared to existing molecules. Expand
Drug-loaded erythrocytes: on the road toward marketing approval
- Vanessa Bourgeaux, J. M. Lanao, B. E. Bax, Y. Godfrin
- Business, Medicine
- Drug design, development and therapy
- 11 February 2016
Although the clinical development of erythrocyte carriers is confronted with regulatory and development process challenges, industrial development is expanding, providing the opportunity in the future to cover a wide range of diseases for which effective therapies are not currently available. Expand
Evaluation of analogues of GalNAc as substrates for enzymes of the mammalian GalNAc salvage pathway.
- S. Pouilly, Vanessa Bourgeaux, F. Piller, V. Piller
- Biology, Medicine
- ACS chemical biology
- 9 February 2012
Synthetic analogues of N-Acetylgalactosamine can help to better define structural requirements of the donor substrates for the enzymes involved in GalNAc metabolism, and those that are incorporated into cells will prove valuable for the development of novel diagnostic and therapeutic tools. Expand
Efficient Enzymatic Glycosylation of Peptides and Oligosaccharides from GalNAc and UTP
- Vanessa Bourgeaux, M. Cadene, F. Piller, V. Piller
- Chemistry, Medicine
- Chembiochem : a European journal of chemical…
- 2 January 2007
Carbohydrates play a major role in a variety of biological processes, and synthetic glycoconjuguates are increasingly used to study the different roles of glycans in vivo and in vitro. Several… Expand
Two-step enzymatic synthesis of UDP-N-acetylgalactosamine.
- Vanessa Bourgeaux, F. Piller, V. Piller
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 December 2005
The method described is a rapid and efficient means to produce UDP-GalNAc as well as analogues like UDP-N-azidoacetylgalactosamine (UDP- GalNAz). Expand
Hypoxia/reoxygenation stress increases markers of vaso-occlusive crisis in sickle SAD mice.
- Emeline Aufradet, Geneviève DeSouza, +8 authors Cyril Martin
- Biology, Medicine
- Clinical hemorheology and microcirculation
The present results give the kinetics of VOC molecular markers in SAD mice which may aid in testing the efficiency of new therapeutic processes against VOC. Expand
Physical activity limits pulmonary endothelial activation in sickle cell SAD mice.
VOC in sickle cell disease results from many pathophysiological mechanisms including sickling of red blood cells, hemolysis, inflammation, vascular adhesion, and reduced nitric oxide (NO) bioavailability. Expand