Van Nam Pham

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The cranial vasculature is essential for the survival and development of the central nervous system and is important in stroke and other brain pathologies. Cranial vessels form in a reproducible and evolutionarily conserved manner, but the process by which these vessels assemble and acquire their stereotypic patterning remains unclear. Here, we examine the(More)
During embryonic development, cell type-specific transcription factors promote cell identities, while epigenetic modifications are thought to contribute to maintain these cell fates. Our understanding of how genetic and epigenetic modes of regulation work together to establish and maintain cellular identity is still limited, however. Here, we show that DNA(More)
The cerebral vasculature provides the massive blood supply that the brain needs to grow and survive. By acquiring distinctive cellular and molecular characteristics it becomes the blood-brain barrier (BBB), a selectively permeable and protective interface between the brain and the peripheral circulation that maintains the extracellular milieu permissive for(More)
Understanding the mechanisms that regulate angiogenesis and translating these into effective therapies are of enormous scientific and clinical interests. In this report, we demonstrate the central role of CDP-diacylglycerol synthetase (CDS) in the regulation of VEGFA signaling and angiogenesis. CDS activity maintains phosphoinositide 4,5 bisphosphate (PIP2)(More)
The paper presents a new system for ECG (ElectroCardioGraphy) signal recognition using different neural classifiers and a binary decision tree to provide one more processing stage to give the final recognition result. As the base classifiers, the three classical neural models, i.e., the MLP (Multi Layer Perceptron), modified TSK (Takagi–Sugeno–Kang) and the(More)
resolution view of the yeast meiotic program revealed by ribosome profiling, skeletal muscle from progenitor and stem cells: development versus regeneration, Wiley Interdis. Rev. Layers of complexity: diverse molecular mechanisms transforming germ layers into organisms, Curr. Sim2 prevents entry into the myogenic program by repressing MyoD transcription(More)
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