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  • Aravind Subramanian, Pablo Tamayo, +8 authors Jill P. Mesirov
  • Computer Science, Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2005 (First Publication: 30 September 2005)
  • Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe aExpand
  • John T Cunningham, Joseph T. Rodgers, Daniel H Arlow, Francisca Isabel Bravo Vázquez, Vamsi K. Mootha, Pere B. Puigserver
  • Biology, Medicine
  • Nature
  • 2007 (First Publication: 1 November 2007)
  • Transcriptional complexes that contain peroxisome-proliferator-activated receptor coactivator (PGC)-1α control mitochondrial oxidative function to maintain energy homeostasis in response to nutrientExpand
  • Sarah E. Calvo, David J. Pagliarini, Vamsi K. Mootha
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2009 (First Publication: 5 May 2009)
  • Upstream ORFs (uORFs) are mRNA elements defined by a start codon in the 5′ UTR that is out-of-frame with the main coding sequence. Although uORFs are present in approximately half of human and mouseExpand