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Polycystic Ovary Syndrome, Insulin Resistance, and Obesity: Navigating the Pathophysiologic Labyrinth
- Joselyn Rojas, Mervin Chávez, Valmore Bermúdez
- Medicine, BiologyInternational Journal of Reproductive Medicine
- 28 January 2014
It is important to thoroughly understand the pathophysiologic interconnections underlying PCOS, in order to provide superior therapeutic strategies and warrant improved quality of life to women with this syndrome.
C-Reactive Protein: Clinical and Epidemiological Perspectives
Changing interest in these clinical findings has led to the creation of modified score systems including C-reactive protein concentrations, in order to enhance risk scores commonly used in clinical practice and offer improved care to patients with cardiovascular disease, which remains the first cause of mortality at the worldwide, national, and regional scenarios.
C-Reactive Protein: An In-Depth Look into Structure, Function, and Regulation
- J. Salazar, M. Martínez, Valmore Bermúdez
- BiologyInternational Scholarly Research Notices
- 15 December 2014
Measurement of serum levels of high-sensitivity CRP has been proposed as a tool for assessment of cardiovascular risk, based on epidemiologic evidence associating high CRP levels with cardiovascular risk.
Dysfunctional High-Density Lipoprotein: An Innovative Target for Proteomics and Lipidomics
- J. Salazar, L. Olivar, E. Ramos, Mervin Chávez-Castillo, Joselyn Rojas, Valmore Bermúdez
- 8 November 2015
Heterogeneous components of the HDL proteome and lipid core suffer alterations, which propel a shift towards a dysfunctional state, where HDL-C becomes proatherogenic, prooxidant, and proinflammatory, which highlights the need for further specialized molecular studies in this aspect.
Sweeteners and Beta-Glucans Improve Metabolic and Anthropometrics Variables in Well Controlled Type 2 Diabetic Patients
A diet incorporating a fat replacer and non-sucrose sweeteners produced a greater improvement in metabolic and anthropometric variables in well controlled type 2 diabetic patients when compared with a diet based on the American Diabetic Association's nutrition recommendations.
Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis
Direct modulation of the molecular pathways concerning these potential macrophage-related targets represents a promising field for new therapeutic alternatives in atherosclerosis and CVD.
Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy
- Joselyn Rojas, Valmore Bermúdez, M. Velasco
- Biology, MedicineJournal of Diabetes Research
- 19 February 2018
Purpose of Review Describing the diverse molecular mechanisms (particularly immunological) involved in the death of the pancreatic beta cell in type 1 and type 2 diabetes mellitus. Recent Findings…
Omega-3 polyunsaturated fatty acids and cardiovascular health: a molecular view into structure and function
The beneficial effects of dietary omega-3 polyunsaturated fatty acids (PUFAs) on CV health appear to vary according to the type of PUFA ingested, dietary sources, daily dosing and individual factors inherent to the subject.
Prevalence and Associated Factors of Insulin Resistance in Adults from Maracaibo City, Venezuela
The prevalence of IR is elevated in the authors' locality and the main determinants of this condition appear to be the presence of obesity, high triacylglycerides, low HDL-C, dysglycemia, and alcohol intake.
Perirenal fat thickness is associated with metabolic risk factors in patients with chronic kidney disease
- L. D’Marco, J. Salazar, Valmore Bermúdez
- Medicine, BiologyKidney research and clinical practice
- 1 September 2019
In CKD patients, the PRF thickness correlated significantly with metabolic risk factors that could affect kidney function and the association of PRF with cardiovascular risk factors and different stages of chronic kidney disease was explored.