Valmik Bhargava

Ravinder K Mittal2
N. Chin Lai2
Wilbur Y. W. Lew1
Su Jin Hong1
2Ravinder K Mittal
2N. Chin Lai
1Wilbur Y. W. Lew
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Muscularis propria of the esophagus is organized into circular and longitudinal muscle layers. Goal of this review is to summarize the role of longitudinal muscle in physiology and pathophysiology of esophageal sensory and motor function. Simultaneous manometry and ultrasound imaging that measure circular and longitudinal muscle contraction respectively(More)
  • Wilbur Y. W. Lew, Evelyn Bayna, Erminia Dalle Molle, Nancy D. Dalton, N. Chin Lai, Valmik Bhargava +3 others
  • 2013
BACKGROUND Circulating subclinical lipopolysaccharide (LPS) occurs in health and disease. Ingesting high fatty meals increases LPS that cause metabolic endotoxemia. Subclinical LPS in periodontal disease may impair endothelial function. The heart may be targeted as cardiac cells express TLR4, the LPS receptor. It was hypothesized that recurrent exposure to(More)
We recently found that an orally directed stretch of the esophagus activates a neurally mediated relaxation of the lower esophageal sphincter (LES). Goals of our study were to characterize the neural mechanisms responsible for axial and transverse stretch-activated responses in the LES. LES pressure was monitored in anesthetized and artificially ventilated(More)
We hypothesized that electrocardiogram (ECG) spatial phase analysis would define a spectrum of intracardiac organization from atrial fibrillation (AF), nonisthmus-dependent and isthmus-dependent atrial flutter (AFL) to supraventricular tachycardias (SVT), and similarly for ventricular arrhythmias. We analyzed arrhythmia ECGs of 33 patients with isthmus (n =(More)
Methods commonly used clinically to assess cardiac function in patients with heart failure include ejection fraction (EF), exercise treadmill testing (ETT), and symptom evaluation. Although these approaches are useful in evaluating patients with heart failure, there are at times substantial mismatches between individual assessments. For example, ETT results(More)
To the Editor, Acute necrotizing esophagitis (ANE) or ''black esoph-agus'' is defined as a circumferential dark pigmentation of the esophagus on endoscopy and mucosal necrosis on histology [1, 2]. Due to its rarity, the etiopathogenesis of this alarming finding is poorly understood [3, 4]. We report a case of ANE in an alcoholic with achalasia and discuss(More)
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