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The ABC of the blood-brain barrier - regulation of drug efflux pumps.

According to the World Health Organization Central nervous system disorders are the major medical challenge of the 21st Century, yet treatments for many CNS disorders are either inadequate or absent.…
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Choroid plexus epithelial monolayers – a cell culture model from porcine brain

The established primary porcine CP model, allowing investigation of complex transport processes, can be used as a reliable tool for analysis of xenobiotic transport across the blood-cerebrospinal fluid barrier (BCSFB).
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Fluo‐cAMP is transported by multidrug resistance‐associated protein isoform 4 in rat choroid plexus

J. Neurochem. (2010) 115, 200–208.
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P-glycoprotein and breast cancer resistance protein expression and function at the blood–brain barrier and blood–cerebrospinal fluid barrier (choroid plexus) in streptozotocin-induced diabetes in rats

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Transport of a fluorescent cAMP analog in teleost proximal tubules.

Cell-to-lumen transport of fluo-cAMP in killifish renal tubules is mediated by a transporter distinct from Mrp2, presumably a teleost form of Mrp4, as well as in membrane vesicles from Spodoptera frugiperda cells containing human MRP4, ATP-dependent and specific uptake offluo- cAMP could be demonstrated.
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Overcoming the Blood Brain Barrier—The Challenge of Brain Drug Targeting

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Characterization of immortalized choroid plexus epithelial cell lines for studies of transport processes across the blood-cerebrospinal fluid barrier

BackgroundTwo rodent choroid plexus (CP) epithelial cell lines, Z310 and TR-CSFB, were compared with primary rat CP epithelial cells and intact CP tissue with respect to transport protein expression,…
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Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles.

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Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus.

Rat and dogfish shark CP transport TR but do so using different basic mechanisms that respond to different regulatory signals, suggesting that neither organic anion transporters nor multidrug resistance-associated proteins (ABCC family) contributed.
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Good vibrations: Bilateral tactile stim1ulation decreases startle magnitude during negative imagination and increases skin conductance response for positive imagination in an affective startle reflex…

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