Valery N. Mukhin

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A number of studies showed association of mental status with heart rate variability. This work discovered a feature of frequency structure of heart rate variability that is associated with mental readiness. In three independent groups of 64, 39, and 19 volunteers by the factor analysis of heart rate periodograms, it has been discovered that there are at(More)
  • V N Mukhin
  • 2013
Alzheimer's disease is the most common cause of the declarative memory disorder: 30-40% cases of dementia among all of age groups, and 50-60% among the people older 65 years. In addition, disorder of declarative memory is the genuine symptom of the disease, which certainly appears on early stage of the disease and it is an obligate diagnostic symptom.(More)
Stress at any age, including at the early stages of postnatal development, leads to changes in the state and reactivity of the stress-related humoral systems, particularly the hypothalamo-hypophyseal-adrenal system (HHAS) and the dynorphin- κ-opioid system (DKOS). These changes are suggested to underlie a number of diseases. Stress-induced changes in the(More)
Literature data and results of our own research suggest that amplitude of periodic modulations of heart rate may be related to the cerebral cortex activity. Verification of this assumption was accomplished by searching for correlation between the heart rate periodogram (as a measure of amplitude of periodic modulations of heart rate at different(More)
Earlier we discovered that heart rate variability was associated with the level of intelligence. The purpose of this study is to confirm this association using more reliable method and to define more precisely the frequency band within which the amplitude of the heart rate modulations is related to intelligence. 13 males (aged 14 to 17) were the study(More)
Existing methods of heart rate recording in animals have shortcomings, which significantly obscure the influence of experimental factors on heart rate. We have developed a method of electrocardiographic recording of heart rate in rats without these drawbacks. To contact the animal limbs used liquid electrodes which are two small baths filled with conductive(More)
Published data and our own results suggest that the amplitude of periodic modulations of heart rate are associated with the level of activation of the cerebral cortex. This suggestion was tested by seeking correlational relationships between heart rate periodograms (a measure of the amplitude of periodic modulations of the heart rate at different(More)
It is known that stress changes state and reactivity of humoral systems of stress, particularly the hypothalamic-pituitary-adrenal system (HPA) and the dynorphin-K-opioid system (DKOS) in any age periods, including ones of early postnatal development. Supposedly these changes are underlying some disorders. Difference in state and reactivity of the HPA(More)
  • V N Mukhin
  • 2013
Alzheimer's disease is a neurodegenerative disorder which is the most common cause of dementia. Studies in last decades allowed identifying the main pathogenetic patterns that can be summarized in three main components which are cholinergic dysfunction, impairment of synaptic plasticity in the neocortex and hippocampal formation, and neuron death in these(More)
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