Valery A Sorokin

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The restriction-modification system is a toxin-antitoxin mechanism of bacterial cells to resist phage attacks. High efficiency comes at a price of high maintenance costs: (1) a host cell dies whenever it loses restriction-modification genes and (2) whenever a plasmid with restriction-modification genes enters a naïve cell, modification enzyme (methylase)(More)
Clustered regularly interspaced short palindromic repeats (CRISPRs) form a recently characterized type of prokaryotic antiphage defense system. The phage-host interactions involving CRISPRs have been studied in experiments with selected bacterial or archaeal species and, computationally, in completely sequenced genomes. However, these studies do not allow(More)
A series of symmetric (Ar-S-S-Ar) and unsymmetric (Ar-S-S-CH2CH2NH3+Cl-) disulfides have been prepared and evaluated as potential cyanoprotective agents. Target compounds have been prepared by known methods and/or methods developed by us specifically for this program, e.g. reaction of a thiol with 2,2'-dithiobis(benzothiazole) (BT-S-S-BT) followed by(More)
There is now a body of evidence to indicate that coupling occurs between the lithosphere–atmosphere–ionosphere prior to earthquake events. Nevertheless the physics of these phenomena and the possibilities of their use as part of an earthquake early warning system remain poorly understood. Proposed here is a programme to create a much greater understanding(More)
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