Valerio Santarelli

Learn More
Sodium channels have four homologous domains (D1-D4) each with six putative transmembrane segments (S1-S6). The highly charged S4 segments in each domain are postulated voltage sensors for gating. We made 15 charge-neutralizing or -reversing substitutions in the first or third basic residues (arginine or lysine) by replacement with histidine, glutamine, or(More)
A domain in the cytoplasmic NH2 terminus of voltage-gated K+ channels supervises the proper assembly of specific tetrameric channels (Li, M., Jan, J. M., and Jan, L. Y.(1992) Science 257, 1225-1230; Shen, N. V., Chen X., Boyer, M. M., and Pfaffinger, P. (1993) Neuron 11, 67-76). It is referred to as a first tetramerization domain, or T1 (Shen, N. V., Chen(More)
Ontology classification is the reasoning service that computes all subsumption relationships inferred in an ontology between concept, role, and attribute names in the ontology signature. OWL 2 QL is a tractable profile of OWL 2 for which ontology classification is polynomial in the size of the ontology TBox. However, to date, no efficient methods and(More)
Ontology classification is the reasoning service that computes all subsumption relationships inferred in an ontology between concept, role, and attribute names in the ontology signature. OWL 2 QL is a tractable profile of OWL 2 for which ontology classification is polynomial in the size of the ontology TBox. However, to date, no efficient methods and(More)
Ontology-based data access (OBDA) is a novel paradigm for accessing large data repositories through an ontology, that is a formal description of a domain of interest. Supporting the management of OBDA applications poses new challenges, as it requires to provide effective tools for (i) allowing both expert and non-expert users to analyze the OBDA(More)
We have constructed a series of deletion mutants of Kv1.3, a Shaker-like, voltage-gated K+ channel, and examined the ability of these truncated mutants to form channels and to specifically suppress full-length Kv1.3 currents. These constructs were expressed heterologously in both Xenopus oocytes and a mouse cytotoxic T cell line. Our results show that a(More)
Sodium channels have four homologous domains (D1-D4) each with six putative transmembrane segments (S1-$6). The highly charged $4 segments in each domain are postulated voltage sensors for gating. We made 15 charge-neutralizing or -reversing substitutions in the first or third basic residues (arginine or lysine) by replacement with histidine, glutamine, or(More)
The Optique project aims at developing an end-to-end system for semantic data access to Big Data in industries such as Statoil ASA and Siemens AG. In our demonstration we present the first version of the Optique system customised for the Norwegian Petroleum Directorate’s FactPages, a publicly available dataset relevant for engineers at Statoil ASA. The(More)
The Optique project aims at providing an end-to-end solution for scalable Ontology-Based Data Access to Big Data integration, where end-users will formulate queries based on a familiar conceptualization of the underlying domain, that is, over an ontology. From user queries the Optique platform will automatically generate appropriate queries over the(More)