Valerii P. Fedotov

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Cell suspensions derived from adult rat anterior pituitary glands were cultured for up to eight days. Prolactin immunoreactivity and/or tritiated thymidine incorporation into DNA of cell nuclei were demonstrated in cells with and without thyroliberin (TRH) and somatostatin (SRIF) treatment. It has been established that (a) TRH, which is effective in(More)
Charcot-Marie-Tooth disease (CMT) and related inherited peripheral neuropathies, including Dejerine-Sottas syndrome, congenital hypomyelination, and hereditary neuropathy with liability to pressure palsies (HNPP), are caused by mutations in three myelin genes: PMP22, MPZ and Cx32 (GJB1). The most common mutations are the 1.5 Mb CMT1A tandem duplication on(More)
We present the results of the molecular genetic study of 26 patients, aged from 12 to 60 years, from 24 unrelated families with limb girdle-muscular dystrophy (LGMD) type 2A. The disease duration varied from 6 months to 30 years. The diagnosis of LGMD 2capital A, Cyrillic was confirmed by molecular genetic methods basing on the presence of a CAPN3 mutation(More)
The review presents data on some peripheral and central structures in the system of perception of chemical stimuli in crayfish and other Decapoda. The hair receptors on chelipeds, antennas, and antennules are innervated by mechano- and chemoreceptor neurons. Antennules are crayfish specialized chemoreceptor organs whose surface contains groups of(More)
1. Judging by the intensity of the synthesis of DNA, the total population of hypophyseal cells of rats of the neonatal and nursing periods is more sensitive to the inhibitory influence of corticosteroids than cells of the hypophyses of animals of the prepubertal period and adults. 2. The hypophyseal cells of rats of the early postnatal period react to(More)
In laboratory experiments, simultaneous continuous recording of the circadian cycle of behavioral reactions and cardiac activity of freshwater crayfish Astacus astacus and Procambarus clarkii was carried out. A non-invasive fiber-optic method of recording of the heart rate (HR) was used. The obtained data were analyzed by the method of variational(More)
Age-related peculiarities of the bromocriptine and melatonin effect on macromolecule biosyntheses in cultured rat pituitary cells were studied during long-term (3 day) incubation. Bromocriptine (10(-9)-10(-7) M) caused dose-dependent inhibition of DNA synthesis in pituitary cells of neonatal rats, but only in maximal dose (10(-7) M) it decreased(More)
Autoradiographic and immunohistochemical experiments were conducted to study the action of thyrotropin-releasing hormone (TRH) on the cell proliferation in 7--8-day monolayer culture or the rat adenohypophysis. There was an increase of the epithelioid and fibroblast-like cells of the S-period of the mitotic cycle 24 hours after the TRH treatment. There were(More)