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UNLABELLED The prevailing concept is that immediate mobilization of bone marrow-derived circulating endothelial progenitor cells (CEP) is a key mechanism mediating tumor resistance to vascular-disrupting agents (VDA). Here, we show that administration of VDA to tumor-bearing mice induces 2 distinct peaks in CEPs: an early, unspecific CEP efflux followed by(More)
The aim of this work is to design new chitosan conjugates able to self-organize in aqueous solution in the form of micrometer-size platelets. When mixed with amphotericin B deoxycholate (AmB-DOC), micro-platelets act as a drug booster allowing further improvement in AmB-DOC anti-Candida albicans activity. Micro-platelets were obtained by mixing oleoyl(More)
In this paper, we address the problem of the segmentation of vessels in images of mouse tumors, with an efficient algorithm that minimizes the user's intervention. For each vessel, two points delimiting its extremities have to be selected. Then, a line inside the vessel is automatically determined based on a Dijkstra-type algorithm. Finally, an original(More)
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