Valerie P J Saw

Learn More
PURPOSE To describe the current management of Acanthamoeba keratitis (AK). DESIGN A perspective based on the literature and author experience. RESULTS Early diagnosis and appropriate therapy are key to a good prognosis. A provisional diagnosis of AK can be made using the clinical features and confocal microscopy, although a definitive diagnosis requires(More)
The advent of serum eye drops, amniotic membrane and limbal stem cell grafts, have transformed the treatment of diseases which result in ocular surface failure. This article provides an overview of ocular surface anatomy and failure, and how the use of serum eye drops, amniotic membrane and limbal epithelial stem cell transplantation has influenced(More)
PurposeCicatrising conjunctival disorders are uncommon, and are difficult to diagnose and manage. This study was designed to assess the annual incidence and underlying diagnosis of patients with cicatrising conjunctivitis (CC) within the United Kingdom.MethodsClinical data of newly diagnosed cases of CC were reported via the British Ophthalmological(More)
Report of a Case. A 37-year-old Nigerian man with a 14year history of bilateral Mooren ulceration had a right corneal perforation and a desmetocele in his severely damaged left eye (Figure, A and B). Snellen visual acuity was 6/60 OD, improving to 6/36 OD with pinhole, and hand movements OS. Systemic cyclosporine at a dosage of 5 mg/kg/d and prednisolone(More)
Purpose: To investigate the effects of thyroxine and hydrocortisone on the viability, proliferation, apoptosis, growth factor and interleukin secretion of human keratocytes in vitro in normal and keratoconic corneas. Methods: Seven normal corneas, not meeting the criteria for corneal transplantation, as well as five corneal buttons from patients with(More)
We read with interest the recent article by Jutley et al1 describing a method of objective assessment of conjunctival fornix depth using a custom-made re-usable instrument created by the authors. We agree wholeheartedly with the authors regarding the value of measuring the fornix depth in cases of cicatrising eye disease, both for assessing the degree of(More)
OBJECTIVE To characterize patterns of chronic ocular disease in patients with Stevens-Johnson syndrome (SJS) and its variant toxic epidermal necrolysis (TEN), and to describe their response to treatment. METHODS Retrospective case series. A review of hospital records of 30 patients (60 eyes) with ocular manifestations of SJS or TEN was carried out. The(More)
Interleukin-13 (IL-13) is the dominant effector cytokine of fibrosis in pulmonary and liver disease. Excessive conjunctival fibrosis in the immunobullous disease ocular mucous membrane pemphigoid (MMP) causes blindness; the pathogenesis of scarring in this disease is incompletely understood. To determine whether IL-13 is involved in conjunctival fibrosis in(More)