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Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs

• Megan J. Wallace, Megan E. Probyn, +5 authors Stuart Brian Hooper
• Respiratory research
• 2009

BACKGROUND Bronchopulmonary dysplasia (BPD) is closely associated with ventilator-induced lung injury (VILI) in very preterm infants. The greatest risk of VILI may be in the immediate period after… (More)

Surfactant before the first inflation at birth improves spatial distribution of ventilation and reduces lung injury in preterm lambs.

• David G Tingay, Megan J. Wallace, +5 authors Peter G Davis
• Journal of applied physiology
• 2014

The interrelationship between the role of surfactant and a sustained inflation (SI) to aid ex utero transition of the preterm lung is unknown. We compared the effect of surfactant administered before… (More)

Protective Ventilation of Preterm Lambs Exposed to Acute Chorioamnionitis Does Not Reduce Ventilation-Induced Lung or Brain Injury

• Samantha K. Barton, Timothy J. M. Moss, +10 authors Graeme Roger Polglase
• PloS one
• 2014

BACKGROUND The onset of mechanical ventilation is a critical time for the initiation of cerebral white matter (WM) injury in preterm neonates, particularly if they are inadvertently exposed to high… (More)

High Bias Gas Flows Increase Lung Injury in the Ventilated Preterm Lamb

• Katinka P. Bach, Carl A. Kuschel, +8 authors Frank H Bloomfield
• PloS one
• 2012

BACKGROUND Mechanical ventilation of preterm babies increases survival but can also cause ventilator-induced lung injury (VILI), leading to the development of bronchopulmonary dysplasia (BPD). It is… (More)

Diffusion Tensor Imaging Colour Mapping Threshold for Identification of Ventilation-Induced Brain Injury after Intrauterine Inflammation in Preterm Lambs

• Dhafer M Alahmari, Béatrice Skiöld, +11 authors Graeme Roger Polglase
• Front. Pediatr.
• 2017

PURPOSE The aim of this study is to examine whether advanced magnetic resonance imaging (MRI) techniques can detect early brain injury caused by intrauterine inflammation and inappropriate initial… (More)

Gene expression profiling during increased fetal lung expansion identifies genes likely to regulate development of the distal airways.

• Foula Sozo, Megan J. Wallace, Valerie A. Zahra, Caitlin E. Filby, Stuart Brian Hooper
• Physiological genomics
• 2006

Growth and development of the fetal lungs is critically dependent on the degree to which the lungs are expanded by liquid; increases in fetal lung expansion accelerate lung growth, whereas reductions… (More)

Lung ultrasound accurately detects pneumothorax in a preterm newborn lamb model.

• Douglas A Blank, Stuart Brian Hooper, +9 authors Graeme Roger Polglase
• Journal of paediatrics and child health
• 2016

AIM Pneumothorax is a common emergency affecting extremely preterm. In adult studies, lung ultrasound has performed better than chest x-ray in the diagnosis of pneumothorax. The purpose of this study… (More)

Effect of sustained inflation vs. stepwise PEEP strategy at birth on gas exchange and lung mechanics in preterm lambs

• David G Tingay, Risha Bhatia, Georg M Schmölzer, Megan J. Wallace, Valerie A. Zahra, Peter G Davis
• Pediatric Research
• 2014

Background:Sustained inflation (SI) at birth facilitates establishment of functional residual capacity (FRC) in the preterm lung, but the ideal lung recruitment strategy is unclear. We have compared… (More)

Diffusion tensor imaging detects ventilation-induced brain injury in preterm lambs

• Dhafer M Alahmari, Kyra Y Y Chan, +9 authors Graeme Roger Polglase
• PloS one
• 2017

PURPOSE Injurious mechanical ventilation causes white matter (WM) injury in preterm infants through inflammatory and haemodynamic pathways. The relative contribution of each of these pathways is not… (More)

Haemodynamic effects of umbilical cord milking in premature sheep during the neonatal transition.

• Douglas A Blank, Graeme Roger Polglase, +10 authors Stuart Brian Hooper
• Archives of disease in childhood. Fetal and…
• 2017

OBJECTIVE Umbilical cord milking (UCM) at birth may benefit preterm infants, but the physiological effects of UCM are unknown. We compared the physiological effects of two UCM strategies with… (More)

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