Valerie A. Gerard

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BACKGROUND The unique and tuneable photonic properties of Quantum Dots (QDs) have made them potentially useful tools for imaging biological entities. However, QDs though attractive diagnostic and therapeutic tools, have a major disadvantage due to their inherent cytotoxic nature. The cellular interaction, uptake and resultant toxic influence of CdTe QDs(More)
BACKGROUND The inherent toxicity of unmodified Quantum Dots (QDs) is a major hindrance to their use in biological applications. To make them more potent as neuroprosthetic and neurotherapeutic agents, thioglycolic acid (TGA) capped CdTe QDs, were coated with a gelatine layer and investigated in this study with differentiated pheochromocytoma 12 (PC12)(More)
Vascular endothelium is a potential target for therapeutic intervention in diverse pathological processes, including inflammation, atherosclerosis, and thrombosis. By virtue of their intravascular topography, endothelial cells are exposed to dynamically changing mechanical forces that are generated by blood flow. In the present study, we investigated the(More)
In this paper, we report on fabrication and optical properties of hollow poly(methyl methacrylate) (PMMA) microspheres loaded with CdSe/CdS core-shell quantum dots. The PMMA microspheres were fabricated using a spray-drying method and investigated using scanning electron microscopy, confocal microscopy, and fluorescent lifetime imaging microscopy.(More)
BACKGROUND Gelatine coating was previously shown to effectively reduce the cytotoxicity of CdTe Quantum Dots (QDs) which was a first step towards utilising them for biomedical applications. To be useful they also need to be target-specific which can be achieved by conjugating them with Folic Acid (FA). RESULTS The modification of QDs with FA via an(More)
Odour emissions are episodic, characterised by periods of high emission rates, interspersed with periods of low emissions. It is frequently the short term, high concentration peaks that result in annoyance in the surrounding population. Dispersion modelling is accepted as a useful tool for odour impact assessment, and two approaches can be adopted. The(More)
The quenching of emission in proximity to metallic surfaces via non-radiative energy transfer is studied for sensing applications. It can also be used for the measurement of distances on the nanoscale. We report on energy transfer from a plane of CdTe quantum dots (QDs) plane to a plane of gold (Au) nanoparticles. Both photoluminescence (PL) and(More)
Colloidal nanocrystal quantum dots have attracted interest for use in light-harvesting and emitting devices. One of the key parameters for such applications is the quantum efficiency. Nanocrystal quantum dots exhibit reduced quantum yield in layers or solids compared with solutions. Optimizing the overall efficiency of the emission is an important goal.(More)
Förster resonant energy transfer (FRET) can be applied to create energy flow on the nano-scale for lightharvesting, colour conversion or sensing applications. The performance of such devices depends on the efficiency of the energy transfer process between the donors and acceptors. In order to achieve high FRET efficiencies, the FRET rate has to(More)
The impact of intra-ensemble Förster resonant energy transfer (FRET) on the optical properties of monodispersed quantum dot (QD) monolayers and a donor/acceptor FRET bilayer structure are presented. The QD structures are characterized by steady-state absorption and photoluminescence (PL) spectroscopy as well as time-resolved PL measurements. The(More)