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Establishment of Genetic Transformation in the Sexually Reproducing Diatoms Pseudo-nitzschia multistriata and Pseudo-nitzschia arenysensis and Inheritance of the Transgene
We report the genetic transformation of the planktonic diatoms Pseudo-nitzschia arenysensis and Pseudo-nitzschia multistriata, members of the widely distributed and ecologically important genusExpand
SMAD4 mutations causing Myhre syndrome result in disorganization of extracellular matrix improved by losartan
Myhre syndrome (MS, MIM 139210) is a connective tissue disorder that presents with short stature, short hands and feet, facial dysmorphic features, muscle hypertrophy, thickened skin, and deafness.Expand
Grazer-induced transcriptomic and metabolomic response of the chain-forming diatom Skeletonema marinoi
Diatoms and copepods are main actors in marine food webs. The prey–predator interactions between them affect bloom dynamics, shape marine ecosystems and impact the energy transfer to higher trophicExpand
Skin fibroblasts of patients with geleophysic dysplasia due to FBN1 mutations have lysosomal inclusions and losartan improves their microfibril deposition defect
Geleophysic dysplasia (GPHYSD) is a disorder characterized by dysmorphic features, stiff joints and cardiac involvement due to defects of TGF‐β signaling. GPHYSD can be caused by mutations in FBN1,Expand
Silencing of lipoxygenase pathways in the diatom genus Pseudo-nitzschia
Diatoms are unicellular eukaryotic organisms that are responsible for about 40% of the marine primary production. They also contribute to the biogeochemical cycles in the oceans. Diatoms produceExpand
Geleophysic dysplasia: novel missense variants and insights into ADAMTSL2 intracellular trafficking
Geleophysic dysplasia (GPHYSD1, MIM231050; GPHYSD2, MIM614185; GPHYSD3, MIM617809) is an autosomal disorder characterized by short-limb dwarfism, brachydactyly, cardiac valvular disease, andExpand