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Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ-opioid and CB1-cannabinoid receptor involvement

• Daniela Braida, Valeria Limonta, +4 authors Mariaelvina Sala
• Psychopharmacology
• 2006

The hallucinatory effect and potential abuse of salvinorin A, the major ingredient of Salvia divinorum, has not been documented in animals. The effects of salvinorin A on the zebrafish (Danio rerio)… (More)

Cellular Mechanisms Underlying the Anxiolytic Effect of Low Doses of Peripheral Δ9-Tetrahydrocannabinol in Rats

• T Rubino, Mariaelvina Sala, +6 authors Daniela Parolaro
• Neuropsychopharmacology
• 2007

We investigated the effect of low doses of intraperitoneal Δ9-tetrahydrocannabinol (THC) on anxiety behavior in rats using the elevated plus maze (EPM). An anxiolytic effect was obtained in a range… (More)

Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward.

• Daniela Braida, Valeria Limonta, +8 authors Mariaelvina Sala
• Biological psychiatry
• 2008

BACKGROUND The recreational drug, Salvinorin A, derived from the plant of Salvia divinorum, is a potent and selective kappa-opioid receptor agonist. The abuse of selective k-agonists is a novel… (More)

5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats.

• Daniela Braida, Valeria Limonta, Lorenzo Malabarba, Alessia D Zani, Mariaelvina Sala
• European journal of pharmacology
• 2007

The mechanism mediating the effects of cannabinoids on anxiety-related responses appear to involve cannabinoid CB1 and non-CB1 receptors. However, other neurotransmitters may play a role in such… (More)

nvolvement of-Opioid and Endocannabinoid System n Salvinorin A-Induced Reward

• aniela Braida, Valeria Limonta, +6 authors Mariaelvina Sala
• 2008

esults: The present results demonstrate the rewarding effects of Salvinorin A in a range of doses between .1 and 40 g/kg SC for onditioned place preference test and .1–.5 g/infusion for ICV… (More)

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