Valeria De Marco

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High-throughput methods to produce a large number of soluble recombinant protein variants are particularly important in the process of determining the three-dimensional structure of proteins and their complexes. Here, we describe a collection of protein expression vectors for ligation-independent cloning, which allow co-expression strategies by implementing(More)
BACKGROUND Acute or subacute stent thrombosis (ST) is a well-described complication usually causing acute coronary syndromes and, in the worst case scenario, sudden cardiac death. In this study, we aimed at exploring the potential role of optical coherence tomography (OCT) in the understanding of the mechanism of ST. METHODS Twenty-one consecutive(More)
OBJECTIVES The goal of this study was to assess the clinical impact of optical coherence tomography (OCT) findings during percutaneous coronary intervention (PCI). BACKGROUND OCT provides unprecedented high-definition visualization of plaque/stent structures during PCI; however, the impact of OCT findings on outcome remains undefined. METHODS In the(More)
Varón de 46 años diagnosticado de adenocarcinoma de próstata Gleason 4+4, PSA 94ng/ml) tratado con radioterapia y hormonoerapia (PSA nadir < 0,1ng/ml). A los 9 meses presenta elevación ioquímica (PSA 2,2 ng/ml) con pruebas de imagen complementaias negativas. Se practica estudio PET/TC con 11C-Colina que muestra úniamente 2 focos hipermetabólicos en el pene,(More)
CONCLUSION Grayscale and VH-IVUS defined high-risk plaque morphology and greater extent of calcification are more common in patients with incomplete revascularization as assessed by rSS. In addition to PROSPECT high-risk plaques (NCL with plaque burden 70% and VH-TCFA), rSS independently predicted 3-year NCL-MACE, in part explaining the long-term high event(More)
OBJECTIVES Assess clinical consequences of acute stent malapposition (ASM) in the context of the multicenter Centro per la Lotta Contro l'Infarto-Optimization of Percutaneous Coronary Intervention (CLI-OPCI) registry. BACKGROUND ASM as important determinant of stent thrombosis (ST) risk remains controversial. METHODS From 2009 to 2013, we(More)
AIMS Recent frequency-domain optical coherence tomography studies showed that a complete removal of thrombotic materials is rarely achieved after percutaneous coronary interventions for ST segment elevation myocardial infarction. Residual intrastent thrombus can embolize distally leading to microcirculatory injury. The aim was to find a possible correlation(More)
Frequency-domain optical coherence tomography (FD-OCT) is a promising intracoronary imaging technique to study atherosclerosis. Indeed, its unprecedented spatial resolution allows the assessment of fibrous cap thickness, lipid pool and features of plaque vulnerability. Aim of this study was to determine the reproducibility of the in vivo FD-OCT measurements(More)
There is a high incidence of pituitary-dependent hyperadrenocorticism (PDH) in Poodle dogs, with family members being affected by the disease, suggesting a genetic involvement. Tpit is an obligate transcription factor for the expression of pro-opiomelanocortingene and for corticotroph terminal differentiation. The aim of the present study was to screen the(More)
AIMS The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome. METHODS AND RESULTS We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were(More)