Valentine Svensson

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The transcriptional programs that govern hematopoiesis have been investigated primarily by population-level analysis of hematopoietic stem and progenitor cells, which cannot reveal the continuous nature of the differentiation process. Here we applied single-cell RNA-sequencing to a population of hematopoietic cells in zebrafish as they undergo thrombocyte(More)
CD4+ T cells are key regulators of the adaptive immune system and can be divided into T helper (Th) cells and regulatory T (Treg) cells. During an immune response Th cells mature from a naive state into one of several effector subtypes that exhibit distinct functions. The transcriptional mechanisms that underlie the specific functional identity of CD4+ T(More)
Differentiation of lymphocytes is frequently accompanied by cell cycle changes, interplay that is of central importance for immunity but is still incompletely understood. Here, we interrogate and quantitatively model how proliferation is linked to differentiation in CD4+ T cells. We perform ex vivo single-cell RNA-sequencing of CD4+ T cells during a mouse(More)
Erratum After the publication of this work [1] it was noticed that four authors were omitted from the author list and author contributions. These authors have now been added to the list, and the updated author contributions are included below. Authors' contributions VP, LHV, KNN, JP and TL carried out ex vivo/in vitro experiments. RM and KRJ carried out in(More)
Mouse embryonic stem cells are dynamic and heterogeneous. For example, rare cells cycle through a state characterized by decondensed chromatin and expression of transcripts, including the Zscan4 cluster and MERVL endogenous retrovirus, which are usually restricted to preimplantation embryos. Here, we further characterize the dynamics and consequences of(More)
  • Valentine Svensson, Kedar Nath, Natarajan, Lam­ha Ly, Ricardo J Miragaia, Charlotte +4 others
  • 2016
High­throughput single cell RNA sequencing (scRNA­seq) has become an established and powerful method to investigate transcriptomic cell­to­cell variation, and has revealed new cell types, and new insights into developmental process and stochasticity in gene expression. There are now several published scRNA­seq protocols, which all sequence transcriptomes(More)
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