Valentina Senatore

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One hundred and ten adults, from borderline to severe levels of mental retardation, were assessed through the outpatient clinic of a university-affiliated mental health center and a large state psychiatric hospital. These patients were included only after they had demonstrated the ability to respond to questions of similar difficulty to those presented in(More)
An inventory of psychopathology (self-report and informant versions) was developed for mentally retarded adults. The inventory was administered to 110 retarded adults from institutional (n = 59) and community (n = 51) settings. Data indicated that both versions of the instrument showed acceptable levels of internal consistency and test-retest reliability.(More)
Depression and psychopathology were assessed in 110 adult patients (ages 18-71 years) classified as borderline, mildly, moderately, or severely mentally retarded. Patients completed modified versions of the Beck Depression Inventory, the Zung Self-Rating Depression Scale, the MMPI depression scale, the Thematic Apperception Test, and the Psychopathology(More)
The effect of hypothyroidism, induced by 6-n-propyl-2-thiouracil (PTU) administration to rats, on the retinoylation reaction and oxidative status was investigated in rat-testes mitochondria. In hypothyroid mitochondria, when compared to euthyroid controls, we found a noticeable increase in the amount of all-trans-retinoic acid (atRA) bound to mitochondrial(More)
The covalent incorporation of [3H]all-trans-retinoic acid into proteins has been studied in tumoural Leydig (MLTC-1) cells. The maximum retinoylation activity of MLTC-1 cell proteins was 710 ± 29 mean ± SD) fmoles/8 × 104 cells at 37 °C. About 90% of [3H]retinoic acid was trichloroacetic acid-soluble after proteinase-K digestion and about 65–75% after(More)
In the current study, two experiments were conducted to establish the reliability of a scale developed with persons of normal intelligence for the assessment of social skill deficits and excesses of the mentally retarded. The experiment was divided into two studies. The first was aimed at establishing which of the 100 items could be accurately rated by(More)
Thirty depressed and 30 nondepressed mentally retarded adults were selected from an initial pool of 110 patients seen at either inpatient or outpatient psychiatric settings in western Pennsylvania. These two groups were compared on each of 14 operationally defined behaviors in an analogue interview setting. Despite the fact that these behaviors are(More)
Ferulic acid plays a chemopreventive role in cancer by inducing tumor cells apoptosis. As mitochondria play a key role in the induction of apoptosis in many cells types, here we investigate the mitochondrial permeability transition (MPT) and the release of cytochrome c induced by ferulic acid and its esters in rat testes mitochondria, in TM-3 and MLTC-1(More)
This study was undertaken to better understand the physiological role of the retinoylation process in steroidogenic tissues. In adrenal gland mitochondria, the retinoylation extent was found equal to that of testes mitochondria but without ATP in the incubation buffer. We pointed out that the endogenous mitochondrial ATP in adrenal glands is much higher(More)
Inpatient and outpatient, emotionally disturbed, borderline to severely mentally retarded adults (N = 110) were assessed to evaluate the relationship of medication to psychiatric diagnosis and symptomatology. Patients were assessed on the Psychiatric Instrument for Mentally Retarded Adults, the Beck Depression Inventory, the Zung Self-Rating Depression(More)