Valentina S Orlova

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This study was designed to investigate the association between null polymorphisms of glutathione S-transferase (GST) M1 and T1 genes and idiopathic male infertility in a Russian population including 203 infertile and 227 fertile men. The nondeletion genotype of the GSTT1 gene was found to be strongly associated with the increased risk of idiopathic male(More)
Gamma-amino butyric acid (GABA) is an active biogenic substance synthesized in plants, fungi, vertebrate animals and bacteria. Lactic acid bacteria are considered the main producers of GABA among bacteria. GABA-producing lactobacilli are isolated from food products such as cheese, yogurt, sourdough, etc. and are the source of bioactive properties assigned(More)
Telomerase activity is known to be regulated by alternative splicing of its catalytic subunit hTERT (human Telomerase Reverse Transcriptase) mRNA. Induction of non-active spliced hTERT leads to inhibition of telomerase activity. However, very little is known about the mechanism of hTERT mRNA alternative splicing. The aim of this study was to determine the(More)
Evaluation of the dose-dependent effects of heavy metals on the viability of a human neuroblastoma SH-SY5Y cell culture showed that 50% cell death was observed in the presence of 5 × 10–4 М lead, 5 × 10–6 М cadmium, 5 × 10–5 М cobalt, and 10–5 М molybdenum. The presence of these metals led to an increase in the level of reactive oxygen species (ROS) (from(More)
The article is devoted to a study of the changes in the activity and chemical composition of the enzymes of the cell envelope of the yeast Candida tropicalis IBFM-303 during growth on n-alkanes and glucose, as well as the transport of n-alkanes through the cell membrane and the redistribution of the cell contents in the process of budding on the indicated(More)
Protective effect of the natural dipeptide carnosine on the antioxidant system of rats under conditions of oxidative stress caused by chronic cadmium administration was investigated. Oxidative status of experimental animals were evaluated based on a number of informative parameters of iron-induced chemiluminescence. It was shown that the introduction of(More)