Valentina Kovalenko

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A comparative study of analgesic and secondary-reinforcing properties of morphine, nalorphine, pentazocine and phencyclidine was carried out on mice. Different rations of their analgesic and reinforcement potencies were revealed. Based on these results, a new indicator--"addictive index" is proposed for characterization of the addictive potential of(More)
Comparative examination of secondary-reinforcing properties of opiate agonists morphine, nalorphine, pentazocine and phencyclidine was carried out on mice using procedure of place preference conditioning in an automatic shuttle-box. Morphine, phencyclidine and pentaxocine (but not nalorphine) produced strong dose-dependent secondary-reinforcing effects.(More)
Experiments on unrestrained rats were carried out to study the effect of intraventricularly injected met- and leu-enkephalins and their synthetic analog Tyr-dAla-Cly-Phe-NH2 on analgesia induced by electrical stimulation of the central gray. It was shown that subanalgesic doses of enkephalins and their synthetic analog facilitated the appearance of(More)
Experiments on rats were made to study the effects of intracerebroventricular injection of met- and leu-enkephalins (ME and LE) during the reactions of self-stimulation and active avoidance (AA) of electrical stimulation of the central gray of the midbrain. Microinjections of LE in doses of 50-100 micrograms facilitated SS of the brain. ME in doses of(More)
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