Valentina Damiano

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DNA methylation is an important epigenetic mechanism of transcriptional control that plays an essential role in several cellular functions. Aberrant DNA methylation in cancer has been frequently associated with downregulation of microRNAs and protein coding genes, such as miR-200c/miR-141 cluster and E-cadherin. Current strategies to assess DNA methylation,(More)
Loss of expression of miR-200 family members has been implicated in cellular plasticity, a phenomenon that accounts for epithelial-to-mesenchymal transition (EMT) and stem-like features of many carcinomas and is considered a major cause of tumor aggressiveness and drug resistance. Nevertheless, the mechanisms of miR-200 downregulation in breast cancer are(More)
This paper describes a gas chromatographic method for the determination of combined residues of prochloraz and its metabolites in various plant materials, including vegetables, fruits, seeds, grains and roots. The method is much simpler than previous ones as it does not require steam distillation; it consists of preliminary extraction of the sample,(More)
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