Valentina Castiglioni

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Huntington's disease (HD) is an inherited neurodegenerative disorder caused by an expanded stretch of CAG trinucleotide repeats that results in neuronal dysfunction and death. Here, The HD Consortium reports the generation and characterization of 14 induced pluripotent stem cell (iPSC) lines from HD patients and controls. Microarray profiling revealed(More)
We propose a SOS-based method for decomposing modal formulae for nondeterministic probabilistic processes. The purpose is to reduce the satisfaction problem of a formula for a process to verifying whether its subprocesses satisfy certain formulae obtained from its decomposition. By our decomposition, we obtain (pre)congruence formats for probabilistic(More)
We study function elimination for Arithmetical Logics. We propose a method allowing substitution of functions appearing in a given formula with functions with less arity. We prove the correctness of the method and we use it to show the decidability of the satisfiability problem for two classes of formulae allowing linear and polynomial terms.
SOS rule formats are sets of syntactical constraints over SOS transition rules ensuring semantical properties of the derived LTS. Given a rule format, our proposal is to try to relax the constraints imposed by the format on each single transition rule at the price of introducing some reasonable constraint on the form of the whole set of rules, obtaining a(More)
In this paper we continue our research line on logical characterizations of behavioral metrics obtained from the definition of a metric over the set of logical properties of interest. This time we provide a characterization of both strong and weak trace metric on nondeterministic probabilistic processes, based on a minimal boolean logic L which we prove to(More)
Bisimulation metrics provide a robust and accurate approach to study the behavior of nondeterministic probabilistic processes. In this paper, we propose a logical characterization of bisimulation metrics based on a simple probabilistic variant of the Hennessy-Milner logic. Our approach is based on the novel notions of mimicking formulae and distance between(More)
Abstract. We propose a method for the decomposition of modal formulae on processes with nondeterminism and probability with respect to Structural Operational Semantics. The purpose is to reduce the satisfaction problem of a formula for a process to verifying whether its subprocesses satisfy certain formulae obtained from the decomposition. To deal with the(More)
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