Vala G Gudnadottir

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The cause of schizophrenia is unknown, but it has a significant genetic component. Pharmacologic studies, studies of gene expression in man, and studies of mouse mutants suggest involvement of glutamate and dopamine neurotransmitter systems. However, so far, strong association has not been found between schizophrenia and variants of the genes encoding(More)
A refined physical map of chromosome 17q21.31 uncovered a 900-kb inversion polymorphism. Chromosomes with the inverted segment in different orientations represent two distinct lineages, H1 and H2, that have diverged for as much as 3 million years and show no evidence of having recombined. The H2 lineage is rare in Africans, almost absent in East Asians but(More)
To determine if neuregulin 1 (NRG1) is associated with schizophrenia in Asian populations, we investigated a Han Chinese population using both a family trio design and a case-control design. A total of 25 microsatellite markers and single nucleotide polymorphisms (SNPs) were genotyped spanning the 1.1 Mb NRG1 gene including markers of a seven-marker(More)
OBJECTIVE To investigate a possible association between the carrier frequency of the N314D mutation in the galactose-1-phosphate uridyl transferase (GALT) gene and endometriosis and linkage to the short arm of chromosome 9, where the GALT gene resides. DESIGN Association and linkage study. SETTING Population material collected for case and family(More)
Hreinn Stefansson1,3, Agnar Helgason1,3, Gudmar Thorleifsson1, Valgerdur Steinthorsdottir1, Gisli Masson1, John Barnard2, Adam Baker1, Aslaug Jonasdottir1, Andres Ingason1, Vala G Gudnadottir1, Natasa Desnica1, Andrew Hicks1, Arnaldur Gylfason1, Daniel F Gudbjartsson1, Gudrun M Jonsdottir1, Jesus Sainz1, Kari Agnarsson1, Birgitta Birgisdottir1, Shyamali(More)
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