Valérie Legout

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The recent prospect of pharmaceutical interventions for cognitive impairment of Down syndrome (DS) has boosted a number of clinical trials in this population. However, running the trials has raised some methodological challenges and questioned the prevailing methodology used to evaluate cognitive functioning of DS individuals. This is usually achieved by(More)
OBJECTIVES To assess whether acute 5-hydroxytryptamine-1A (5-HT1A)-receptor-mediated corticotropin, cortisol, and temperature responses are maintained after 3 weeks of treatment with controlled-release (CR) ipsapirone and fluoxetine compared with placebo and whether changes are reversible after cessation of treatment. METHODS This was a randomized(More)
Repinotan is a high-affinity, selective, full agonist of the 5HT1A-receptor subtype with neuroprotective properties. This paper presents the results of a randomized, double-blind, placebo-controlled study examining the safety and tolerability of three different doses of repinotan in patients with severe traumatic brain injury. Sixty patients were enrolled(More)
OBJECTIVE To compare the accuracy of daily and recalled pain measurements in hip and knee osteoarthritis (OA). METHODS A prospective study investigating pain intensity over 29 days in patients with painful OA. Pain was assessed on days 1 and 29 during visits. Between these two visits, daily (worst, least, usual, mean, at rest and during daily life) and(More)
Objective: The pharmacokinetics and tolerance of idebenone after single or repeated doses have been studied in young patients with mitochondrial encephalomyopathy. Results: No significant adverse effects were noted. In 3 out of 7 patients idebenone induced overall stimulation and improvement in arousal. Plasma concentrations of idebenone and its main(More)
BACKGROUND AND AIMS Neuropathic pain has been shown to be accompanied by cognitive impairment, but the specific impact of postherpetic neuropathic pain on cognitive processes has not been explored. This study aims to evaluate the impact of pain on several domains of cognition in older patients with postherpetic neuralgia (PHN). METHODS This(More)
STUDY DESIGN A prospective study. OBJECTIVE To identify factors potentially influencing patient self-evaluation of chronic low back pain (CLBP) and their interactions. SUMMARY OF BACKGROUND DATA The impact of the time, context, and/or recall on the self-assessment of chronic pain intensity remains poorly understood. METHODS A prospective study(More)
BACKGROUND Neuropathic pain is often severe and adversely affects patients' quality of life. OBJECTIVE To perform a retrospective, observational study investigating the efficacy and safety of treating refractory chronic neuropathic pain with 5% lidocaine-medicated plaster, in patients attending pain centres. METHODS Medical records from 467 patients(More)
BACKGROUND Assessment of pain in children is an important aspect of pain management and can be performed by observational methods or by self-assessment. The Faces Pain Scale-Revised (FPS-R) is a self-report tool which has strong positive correlations with other well established self-report pain intensity measures. It has been recommended for measuring pain(More)