Valérie Jotterand

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OBJECTIVES This study was designed to assess the prevalence of major cardiovascular risk factors in familial premature coronary artery disease (P-CAD), affecting two or more siblings within one sibship. BACKGROUND Premature CAD has a genetic component. It remains to be established whether familial P-CAD is due to genes acting independently from major(More)
Cases of severely hypercholesterolemic HIV-infected children taking protease inhibitors (PIs) have been reported. Because high cholesterol levels (> or =15 mmol/L), as seen in homozygous familial hypercholesterolemia (FH), may lead to heart disease in childhood, the authors performed a systematic retrospective survey of all plasma lipid levels recorded for(More)
BACKGROUND Hypertension, hypercholesterolemia, obesity and smoking are highly prevalent among patients with familial premature coronary artery disease (FP-CAD). Whether these risk factors equally affect other family members remains unknown. METHODS We examined 222 FP-CAD patients, 158 unaffected sibs, 197 offspring and 94 spouses in 108 FP-CAD families (>(More)
Collapsing focal segmental glomerulosclerosis is well described in its idiopathic form, mostly seen in young African American patients, and in association with HIV virus. Its clinical presentation typically includes proteinuria and renal failure rapidly progressing to end stage renal disease. However, a new form has recently been described related to(More)
Ischemic Heart Disease (IHD) is difficult to diagnose since most of the symptoms and clinical presentations are similar to other diseases. It is a very common, harmful disease, which is identified mostly during the mortality of an individual. The objective is to build a clinical decision support system, which will diagnose the presence of IHD with an(More)
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