Valérie André

Learn More
Antisense oligonucleotides (ASOs) have potential as anti-cancer agents by specifically modulating genes involved in tumorigenesis. However, little is known about ASO biodistribution and tissue pharmacokinetics (PKs) in humans, including whether sufficient delivery to target tumor tissue may be achieved. In this preliminary study in human subjects, we used(More)
BACKGROUND Acute myeloid leukemia (AML) is a life-threatening malignancy with limited treatment options in chemotherapy-refractory patients. A first-in-human dose study was designed to investigate a safe and biologically effective dose range for LY2457546, a novel multikinase inhibitor, in patients with relapsed AML. METHODS In this nonrandomized,(More)
  • Malin André, To Lova, Hanna, Hedvig And Lotten, I André, M Borgquist +8 others
  • 2004
Rules of thumb and management of common infections in general practice " No rule so good as rule for thumb, if it hits ". Abstract This thesis deals with problem solving of general practitioners (GPs), which is explored with different methods and from different perspectives. The general aim was to explore and describe rules of thumb and to analyse the(More)
  • 1