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Recently, there has been renewed interest in the role of tumor stem cells (TSCs) in tumorigenesis, chemoresistance, and relapse of malignant tumors including osteosarcoma. The potential exists to improve osteosarcoma treatment through characterization of TSCs and identification of therapeutic targets. Using transcriptome, proteome, immunophenotyping for(More)
Recent developments in isolation and characterization of tumor stem cells (TSCs) have opened new possibilities for developing TSC-targeted therapies. Extensive efforts have been made to ascertain markers of TSCs, including cell surface, enzymatic, gene expression profile, and functional markers. These markers and the technologies used to identify and(More)
Despite a decade of active research, there has been a marked lack in clone detection techniques that scale to large repositories for detecting near-miss clones. In this paper, we present a token-based clone detector, SourcererCC, that can detect both exact and near-miss clones from large inter-project repositories using a standard workstation. It exploits(More)
Given the availability of large source-code repositories, there has been a large number of applications for large-scale clone detection. Unfortunately, despite a decade of active research, there is a marked lack in clone detectors that scale to big software systems or large repositories, specifically for detecting near-miss (Type 3) clones where significant(More)
Hyperthermia can be produced by near-infrared laser irradiation of gold nanoparticles present in tumors and thus induce tumor cell killing via a bystander effect. To be clinically relevant, however, several problems still need to be resolved. In particular, selective delivery and physical targeting of gold nanoparticles to tumor cells are necessary to(More)
We sought to develop a cancer-targeted, infectivity-enhanced oncolytic adenovirus that embodies a capsid-labeling fusion for noninvasive dual-modality imaging of ovarian cancer virotherapy. A functional fusion protein composed of fluorescent and nuclear imaging tags was genetically incorporated into the capsid of an infectivity-enhanced conditionally(More)
Metallic nanoparticles (NPs) can be used for the diagnosis, imaging, and therapy of tumors and cardiovascular disease. However, targeted delivery of NPs to specific cells remains a major limitation for clinical realization of these potential treatment options. Herein, a novel strategy for the specific coupling of NPs to a targeted adenoviral (Ad) platform(More)
Over the past few years, researchers have implemented various algorithms to improve the scalability of clone detection. Most of these algorithms focus on scaling vertically on a single machine, and require complex intermediate data structures (e.g., suffix tree, etc.). However, several new use-cases of clone detection have emerged, which are beyond the(More)
One of the perceived values of open source software is the idea that many eyes can increase code quality and reduce the amount of bugs. This perception, however, has been questioned by some due the lack of supporting evidence. This paper presents an empirical analysis focusing on the relationship between the utilization of open source components and their(More)
In this paper, we present data downloaded from Maven, one of the most popular component repositories. The data includes the binaries of 186,392 components, along with source code for 161,025. We identify and organize these components into groups where each group contains all the versions of a library. In order to asses the quality of these components, we(More)