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We describe a neural spike-sorting processor that provides unsupervised clustering simultaneously for 16 channels. The use of a two-stage clustering algorithm, noise-tolerant distance metric, and selectively clocked high-V T register arrays makes online clustering feasible for implementation. The spike-sorting processor has a power consumption of 75µW at(More)
Wireless neural recording systems are subject to stringent power consumption constraints to support long-term recordings and to allow for implantation inside the brain. In this paper, we propose using a combination of on-chip detection of action potentials ("spikes") and compressive sensing (CS) techniques to reduce the power consumption of the neural(More)
This paper shows that due to their negligibly low leakage, in certain applications, chips utilizing power gates built even with today's relatively large, high-voltage micro-electro-mechanical (MEM) relays can achieve lower total energy than those built with CMOS transistors. A simple analysis provides design guidelines for off-time and savings estimates as(More)
CONTEXT Obsessive-compulsive disorder (OCD) is the fourth most common mental disorder and is diagnosed nearly as often as asthma and diabetes mellitus. Over the last decade, the inhibition of burying of glass marbles by mice has been used as an index of anti-OCD drug action in the so-called marble-burying test. Lagenaria siceraria (Molina) Standley (LS),(More)
Š This course focuses on advanced concepts of VLSI circuit and system design in state of the art CMOS technologies. − Circuit-level optimization using gate size, supply and threshold voltage; layout of circuit blocks optimized for speed, power, or area. − Advanced concepts of retiming, place and route will be employed in class projects, in addition to the(More)
—This report presents the design of a multi – channel neural signal processing engine using the Matlab/Simulink based design flow. Several algorithms used for spike sorting are analyzed in terms of their detection accuracy vs. hardware complexity. The " complexity – accuracy " optimal algorithms are implemented in Simulink using the Synplify DSP Blockset.(More)
Wireless sensing of electrophysiological signals in day-to-day life will enable various clinical, research, and wellness applications. This paper reviews the design requirements of biosignal recording interfaces for use in remote, unconstrained environments and put the performance achieved by state-of-the-art designs in perspective. In particular, we(More)