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DNA methylation is crucial for gene regulation and maintenance of genomic stability. Rat has been a key model system in understanding mammalian systemic physiology, however detailed rat methylome remains uncharacterized till date. Here, we present the first high resolution methylome of rat liver generated using Methylated DNA immunoprecipitation and high(More)
A major fraction of the transcriptome of higher organisms comprised an extensive repertoire of long non-coding RNA (lncRNA) which express in a cell type and development stage-specific manner. While lncRNAs are a proven component of epigenetic gene expression modulation, epigenetic regulation of lncRNA itself remains poorly understood. Here we have analysed(More)
A quantitative structure-activity relationship (QSAR) analysis was performed on a data set of 104 molecules showing N-type calcium channel blocking activity. Several types of descriptors, including electrotopological, structural, thermodynamics and ADMET, were used to derive a quantitative relationship between N-type calcium channel blocking activity and(More)
We have developed a graphical user interface based dendrimer builder toolkit (DBT) which can be used to generate the dendrimer configuration of desired generation for various dendrimer architectures. The validation of structures generated by this tool was carried out by studying the structural properties of two well known classes of dendrimers:(More)
The online fingerprints by biometric system is not widely used now a days and there is less scope as user is friendly with the system. This paper represents a framework and applying the latent fingerprints obtained from the crime scene. These prints would be matched with our database and we identify the criminal. For this process we have to get the(More)
Two simple and sensitive spectrophotometric and RP-HPLC methods are described for the determination of Olmesartan Medoxomil. The first method Spectrophotometry was based on the standard curve. Olmesartan Medoxomil exhibits λmax at 258 nm. Quantitative estimation of Olmesartan Medoxomil was carried out the standard calibration curve at 258 nm. The second(More)
Software project estimation is the process of analyzing the resource requirements for the given time duration of product development. Cost estimation models are used for calculating the associated amount required for developing the stakeholder's requirement within the defined time boundaries. Among several models available for the cost estimation of(More)
This paper describes the approach for Subtask-1 of the FIRE-2015 Shared Task on Mixed Script Information Retrieval. The subtask involved multilingual language identification (including mixed words and anomalous foreign words), named entity recognition (NER) and subclassification. The proposed methodology starts with cleaning the data and then extracting(More)