Vahid Rezania

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We develop a physiologically-based lattice model for the transport and metabolism of drugs in the functional unit of the liver, called the lobule. In contrast to earlier studies, we have emphasized the dominant role of convection in well-vascularized tissue with a given structure. Estimates of convective, diffusive and reaction contributions are given. We(More)
We extend a physiologically-based lattice model for the transport and metabolism of drugs in the liver lobule (liver functional unit) to consider structural and spatial variability. We compare predicted drug concentration levels observed exiting the lobule with their detailed distribution inside the lobule, and indicate the role that structural variation(More)
It has been suggested that microtubules and other cytoskeletal filaments may act as electrical transmission lines. An electrical circuit model of the microtubule is constructed incorporating features of its cylindrical structure with nanopores in its walls. This model is used to study how ionic conductance along the lumen is affected by flux through the(More)
One of the major issues in current pharmaceutical development is potential hepatotoxicity and drug-induced liver damage. This is due to the unique metabolic processes performed in the liver to prevent accumulation of a wide range of chemicals in the blood. Recently, we developed a physiologically-based lattice model to address the transport and metabolism(More)
Microtubules (MTs) are intra-cellular cylindrical protein filaments. They exhibit a unique phenomenon of stochastic growth and shrinkage, called dynamic instability. In this paper, we introduce a theoretical framework for applying Compressive Sensing (CS) to the sampled data of the microtubule length in the process of dynamic instability. To reduce data(More)
In this paper we propose a microscopic model to study the polymerization of microtubules (MTs). Starting from fundamental reactions during MT's assembly and disassembly processes, we systematically derive a non-linear system of equations that determines the dynamics of microtubules in 3D. We found that the dynamics of a MT is mathematically expressed via a(More)
The loss of angular momentum through gravitational radiation, driven by the excitation of r-modes, is considered in neutron stars having rotation frequencies smaller than the associated critical frequency. We find that for reasonable values of the initial amplitudes of such pulsation modes of the star, being excited at the event of a glitch in a pulsar, the(More)
We use the post-Newtonian (pn) order of Liouville's equation to study the normal modes of oscillation of a spherically symmetric relativistic system. Perturbations that are neutral in Newtonian approximation develop into a new sequence of normal modes. In the first pn order; a) their frequency is an order q smaller than the classical frequencies, where q is(More)
In this paper, we develop a spatio-temporal modeling approach to describe blood and drug flow, as well as drug uptake and elimination, on an approximation of the liver. Extending on previously developed computational approaches, we generate an approximation of a liver, which consists of a portal and hepatic vein vasculature structure, embedded in the(More)