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Detection of nucleophosmin and FMS-like tyrosine kinase-3 gene mutations in acute myeloid leukemia
Background and Objectives : Nucleophosmin gene mutations are frequently reported in acute myeloid leukemia (AML) patients with normal karyotype, which is also frequently associated with internalExpand
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Frequency of CYP1A1*2C Polymorphism in Patients with Leukemia in the Iranian Population
Background: CYP1A1, a member of the cytochrome P450 (CYP) enzymes, plays a very important role in metabolizing carcinogens. The aim of this case-control study was to detect the frequency of CYP1A1*2CExpand
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Polymorphisms of the Methylene Tetrahydrofolate Reductase and Susceptibility to Acute Lymphoblastic Leukemia in Children
Background: Correlation between epigenetic factors and their effects on hematopoietic cells has led to a study of 2 common functional polymorphisms (C677T and A1298C) of 5,10methyleneExpand
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Detection and assessment of the frequency of NPM1 and FLT3 ITD mutations in acute myeloid leukemia patients
Background and Objectives NPM1/Nucleophismin/B23 is a phosphoprotein with high expression in the proliferating cells. NPM1+AMLs are also frequently associated with FLT3 ITD mutations. The purposes ofExpand
A Single Nucleotide Polymorphism -1131T>C in the Apolipoprotein A5 Gene Modulates the Levels of Triglyceride
Background: The recently discovered apolipoprotein A5 (APOA5) gene has been shown to be important in determining plasma triglyceride (TG) levels, a major cardiovascular disease risk factor. WeExpand
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