Vadrevu Subbarao

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BACKGROUND Smooth muscle cell (SMC) proliferation is a critical component of neointimal formation in many models of vascular injury and in human lesions as well. Cell-cycle inhibition by gene transfer techniques can block SMC proliferation and lesion formation in animal models, although these methods are not yet applicable to the treatment of human disease.(More)
The hepatic effects of ciprofibrate, a potent peroxisome proliferator, were evaluated in male C57BL/6N mice, a mouse strain with very low incidence of spontaneous liver tumour development. Dietary feeding of ciprofibrate (0.0125% or 0.025% w/w) for 2 weeks resulted in a marked proliferation of peroxisomes (9-fold increase) and several-fold increase (8- to(More)
/v-Nitroso-2,6-dimethylmorpholine (NNDM) is an indirect ni-trosamine carcinogen which induces ductal adenocarcinoma of the pancreas in the Syrian golden hamster. NNDM is oxidized by normal male hamster pancreas postmitochondrial superna-tants (S-9) in the presence of reduced nicotinamide adenine dinucleotide phosphate and oxygen to give three major identi(More)
Dehydroepiandrosterone, a major secretory steroid hormone of the human adrenal gland, possesses mitoinhibitory and anticarcinogenic properties. It also induces peroxisome proliferation in the livers of rats and mice. Because peroxisome proliferators exhibit hepatocarcinogenic potential, it is necessary to examine the long term hepatic effects of(More)
Peroxisome proliferators cause liver cell proliferation in addition to other pleiotropic effects such as peroxisome proliferation and induction of certain peroxisomal and cytosolic enzymes in liver. Since dexamethasone has been shown to inhibit mitogen-induced liver cell hyperplasia, we examined whether dexamethasone inhibits only cell proliferation without(More)
A 60-year-old white woman presented with a history of exertional shortness of breath rapidly progressing to or-thopnea and episodes of paroxysmal nocturnal dyspnea over a period of 4 weeks. Her past medical history included hyperten-sion; sick sinus syndrome, for which she had received a pacemaker; and a left carotid endarterectomy. Physical examination(More)
N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine (HPOP) is a complete pancreatic carcinogen in female hamsters at a dose of 210 mg/kg given via an Alzet 2001 pump implanted s.c. Ultimate carcinogenic metabolites of HPOP target DNA to yield 7-and O6-methylguanines (7-mGua, O6-mGua) and 7- and O6-hydroxypropylguanines (7-HpGua, O6-HpGua). During continuous(More)
/v-Nitroso-2,6-dimethylmorpholine (NNDM) is an indirect ni-trosamine carcinogen which induces ductal adenocarcinoma of the pancreas in the Syrian golden hamster. NNDM is oxidized by normal male hamster pancreas postmitochondrial superna-tants (S-9) in the presence of reduced nicotinamide adenine dinucleotide phosphate and oxygen to give three major identi(More)
Under a copper-deficient regimen, pan-creatic cells in the adult rat can be found to undergo differentiation into hepatocytes. Pancreatic hepatocytes induced in male and female rats were examined for the expression of the androgen-inducible hepatic protein, o~-globulin. C~2u-Globulin protein was demonstrable by immunoperoxidase method in all the pancreatic(More)
(NBOP), a postulated 3-metabolite of din -propyl-nitrosamine, has been found to be a potent carcinogen in different species of animals (Pour et al., 1977a; Rao & Pour, 1978; Pour et al., 1979). In hamsters, a single or repeated s.c. administration of NBOP (Pour et al., 1977a, 1978) is reported to cause a high incidence of pancreatic ductal tumours. Because(More)