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We report observation of a fine structure component in backscattered light from mucosal tissue which is periodic in wavelength. This structure is ordinarily masked by a diffusive background. We have identified the origin of this component as being due to light which is Mie scattered by surface epithelial cell nuclei. By analyzing the amplitude and frequency(More)
We report what we believe to be the first evidence of localized nanoscale photonic jets generated at the shadow-side surfaces of micronscale, circular dielectric cylinders illuminated by a plane wave. These photonic nanojets have waists smaller than the diffraction limit and propagate over several optical wavelengths without significant diffraction. We have(More)
Recently, there has been a major thrust to understand biological processes at the nanoscale. Optical microscopy has been exceedingly useful in imaging cell microarchitecture. Characterization of cell organization at the nanoscale, however, has been stymied by the lack of practical means of cell analysis at these small scales. To address this need, we(More)
Background & Aims: Identification of preneoplastic changes in histologically normal epithelium (the " field effect ") could provide a powerful screening tool for colo-rectal cancer. However, to date, reliable detection has not been possible. We have recently developed a new generation of optical technology, 4-dimensional elastic light-scattering(More)
Light scattered from biological tissues can exhibit an inverse power law spectral component. We develop a model based on the Born approximation and von Karman (self-affine) spatial correlation of submicron tissue refractive index to account for this. The model is applied to light scattering spectra obtained from excised esophagi of normal and(More)
Microarrays have enabled the determination of how thousands of genes are expressed to coordinate function within single organisms. Yet applications to natural or engineered communities where different organisms interact to produce complex properties are hampered by theoretical and technological limitations. Here we describe a general method to accurately(More)
We determine the relationship between the depolarization properties of inhomogeneous particles and the statistical parameters of their internal refractive-index distributions. Our analysis demonstrates that the linear depolarization ratio of backscattered light by an inhomogeneous particle is approximately proportional to both the squared standard deviation(More)
We investigated the detection of dielectric nanoparticles using static light scattering spectroscopy (LSS) in the UV range (from 250 to 390 nm). The light scattered by the polystyrene nanospheres in the backward direction were collected by means of an optical fiber probe and a charge-coupled device (CCD) spectrograph. The size distributions of the(More)
At the forefront of ecosystems adversely affected by climate change, coral reefs are sensitive to anomalously high temperatures which disassociate (bleaching) photosynthetic symbionts (Symbiodinium) from coral hosts and cause increasingly frequent and severe mass mortality events. Susceptibility to bleaching and mortality is variable among corals, and is(More)
Rigorous numerical modeling of optical systems has attracted interest in diverse research areas ranging from biophotonics to photolithography. We report the full-vector electromagnetic numerical simulation of a broadband optical imaging system with partially coherent and unpolarized illumination. The scattering of light from the sample is calculated using(More)