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Oxidative stress contributes to muscular fatigue. GSH is the major intracellular antioxidant, the biosynthesis of which is dependent on cysteine availability. We hypothesized that supplementation with a whey-based cysteine donor [Immunocal (HMS90)] designed to augment intracellular GSH would enhance performance. Twenty healthy young adults (10 men, 10(More)
OBJECTIVE Lung disease in cystic fibrosis (CF) is characterized by a neutrophilic inflammatory response. This can lead to the production of oxidants, and to oxidative stress in the lungs. Glutathione (GSH) represents the primary intracellular antioxidant, and provides an important defense in the epithelial lining fluid. Evidence suggests that lymphocyte GSH(More)
The effects of long-chain triglycerides and a mixture of free fatty acid on the adaptive response to small bowel resection were examined. Rats with a 50% small bowel resection were divided into four groups. Two received 10% of their calories intragastrically either as corn oil or as free fatty acid and the remaining calories intravenously while the two(More)
The case-cohort design (Prentice, 1986) and the synthetic case-& Breslow, 1978) are economical alternatives to the traditional full-cohort design for the study of chronic diseases. By processing covariate information on all the events and only a fraction of those subjects who do not experience the outcome of interest, substantial savings can be realized in(More)
The levels of insulin-like growth factor II/mannose-6-phosphate (IGF-II/Man-6-P) receptor and the insulin-like growth factor I (IGF-I) receptor were measured in the intestinal epithelium after 50% resection of the small intestine. Controls were either pair-fed to match the reduced food intake of the resected group or fed ad libitum. [125I]IGF-II binding was(More)
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