Genetic, hormonal and metabolic aspects of PCOS: an update
- V. de Leo, M. C. Musacchio, V. Cappelli, M. G. Massaro, G. Morgante, F. Petraglia
- Medicine, BiologyReproductive Biology and Endocrinology
- 16 July 2016
Polycystic ovary syndrome is a complex endocrine disorder affecting 5–10 % of women of reproductive age and patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.
Insulin-lowering agents in the management of polycystic ovary syndrome.
- V. de Leo, A. La Marca, F. Petraglia
- Medicine, BiologyEndocrine reviews
- 1 October 2003
In a high percentage of patients, treatment with metformin is followed by regularization of menstrual cycle, reduction in hyperandrogenism and in cardiovascular risk factors, and improvement in response to therapies for induction of ovulation.
Effects of metformin on gonadotropin-induced ovulation in women with polycystic ovary syndrome.
- V. de Leo, A. La Marca, A. Ditto, G. Morgante, A. Cianci
- Medicine, BiologyFertility and Sterility
- 1 August 1999
Infertility and psychiatric morbidity.
- C. Sbaragli, G. Morgante, A. Goracci, Tara Hofkens, V. de Leo, P. Castrogiovanni
- Medicine, PsychologyFertility and Sterility
- 1 December 2008
Mullerian-inhibiting substance in women with polycystic ovary syndrome: relationship with hormonal and metabolic characteristics.
- A. La Marca, R. Orvieto, S. Giulini, V. Jasonni, A. Volpe, V. de Leo
- Medicine, BiologyFertility and Sterility
- 1 October 2004
Anti-Müllerian hormone concentrations in maternal serum during pregnancy.
- A. La Marca, S. Giulini, R. Orvieto, V. de Leo, A. Volpe
- Medicine, BiologyHuman Reproduction
- 1 June 2005
It is hypothesized that the profile of the new marker of ovarian activity AMH may indicate that initial non-cyclic ovarian follicular activity during pregnancy is not abolished, and FSH, does not seem to play a direct role on AMH synthesis and secretion.
Effects of estrogens and androgens on erythrocyte antioxidant superoxide dismutase, catalase and glutathione peroxidase activities during the menstrual cycle.
- C. Massafra, D. Gioia, A. Bernabei
- Biology, MedicineJournal of Endocrinology
- 1 December 2000
The findings indicate that physiological ovarian estradiol production during the menstrual cycle may have an important role in regulating erythrocyte glutathione peroxidase activity.
Clinical, endocrine and metabolic effects of acarbose, an alpha-glucosidase inhibitor, in PCOS patients with increased insulin response and normal glucose tolerance.
- L. Ciotta, A. Calogero, M. Farina, V. de Leo, A. La Marca, A. Cianci
- Medicine, BiologyHuman Reproduction
- 1 October 2001
This is the first report showing a reduction of the acne/seborrhoea score in hyperinsulinaemic patients with PCOS treated with acarbose, and this improvement was associated with a significant decrease of the insulin response to oral glucose load and of LH and androgen serum concentrations and with asignificant rise of sex hormone binding globulin concentration.
The administration of metformin during pregnancy reduces polycystic ovary syndrome related gestational complications.
- V. de Leo, M. C. Musacchio, P. Piomboni, A. Di Sabatino, G. Morgante
- MedicineEuropean Journal of Obstetrics, Gynecology, and…
- 1 July 2011
Insulin-dependent diabetes in men is associated with hypothalamo-pituitary derangement and with impairment in semen quality.
- B. Baccetti, A. La Marca, V. de Leo
- Medicine, BiologyHuman Reproduction
- 1 October 2002
The reproductive impairment recognized in men with diabetes could be the result of interference by the disease on the hypothalamo-pituitary-testicular axis at multiple levels, as indicated by the reduced gonadotrophin response to appropriate stimuli and by the abnormal ultrastructure of ejaculated sperm.
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