• Publications
  • Influence
Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice.
TLDR
The acceleration in lesion size concomitant to the severely impaired NO-mediated responses indicates that lack of endogenous NO is an important progression factor of atherosclerosis in the apoE-KO mouse. Expand
Fasudil, a Rho-Kinase Inhibitor, Attenuates Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E–Deficient Mice by Inhibiting Apoptosis and Proteolysis
TLDR
It is demonstrated that inhibition of Rho-kinase by fasudil attenuated Ang II–induced AAA through inhibition of both apoptosis and proteolysis pathways. Expand
Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice.
TLDR
Results demonstrate for the first time that aortic stiffness determined by PWV increases in 13-mo-old apoE-KO mice, indicating endothelial dysfunction and elastic destruction in vascular wall caused by atherosclerosis may have contributed. Expand
Anti-atherosclerotic effect of simvastatin depends on the presence of apolipoprotein E.
TLDR
The results suggest that the therapeutic effects of simvastatin may depend on the presence of a functional apolipoprotein E. Expand
Enalapril attenuates angiotensin II-induced atherosclerosis and vascular inflammation.
TLDR
An important role for Ang II-independent mechanisms in the antiatherogenic and anti-inflammatory effects of ACE inhibitors is suggested. Expand
A novel inhibitor of activated thrombin activatable fibrinolysis inhibitor (TAFIa) - part II: enhancement of both exogenous and endogenous fibrinolysis in animal models of thrombosis.
TLDR
These studies demonstrated that inhibition of TAFIa by BX 528 enhanced both the exogenous (induced by a low dose of t-PA) and endogenous (LPS-induced resistance) thrombolysis without increasing the bleeding risk in four different animal models of thrombosis. Expand
Endothelial NO Synthase Deficiency Promotes Smooth Muscle Progenitor Cells in Association With Upregulation of Stromal Cell-Derived Factor-1α in a Mouse Model of Carotid Artery Ligation
TLDR
It is determined that constitutive eNOS inhibits SDF-1α expression and provides an important vasculoprotective mechanism for intact endothelium to limit SMC proliferation and recruitment in response to vascular injury and enhanced CAL-induced intimal cell proliferation in the ligated arteries. Expand
17&bgr;-Estradiol Attenuates Development of Angiotensin II–Induced Aortic Abdominal Aneurysm in Apolipoprotein E–Deficient Mice
TLDR
Testing the hypothesis that estrogen can attenuate Ang II–induced AAA in apolipoprotein E–deficient mice via its anti-inflammatory mechanism suggests that attenuation of AAA by E2 is associated with inhibition of proinflammatory gene expression. Expand
Angiotensin II injures the arterial wall causing increased aortic stiffening in apolipoprotein E-deficient mice.
TLDR
The present data indicate that ANG II injures the artery wall in multiple ways and arterial stiffening may be a common outcome of ANG II-induced arterial damage. Expand
A novel P2Y(12) adenosine diphosphate receptor antagonist that inhibits platelet aggregation and thrombus formation in rat and dog models.
TLDR
It is demonstrated that the orally active reversible P2Y(12) receptor antagonist, BX 667, has a wider therapeutic index than clopidogrel in experimental models of thrombosis. Expand
...
1
2
3
...