• Publications
  • Influence
Structural variability and new intermolecular interactions of Z-DNA in crystals of d(pCpGpCpGpCpG).
TLDR
The molecules show striking new features when compared with previously determined Z-DNA structures: 1) the bases in one duplex have a large inclination with respect to the helical axis, which alters the overall shape of the molecule and some cytosine nitrogens interact by hydrogen bonding with phosphates in neighbor molecules. Expand
Oligonucleotide-Peptide Conjjugates for RNA Cleavage
Abstract Directed cleavage of RNA phosphodiester bonds by peptidyloligodeoxyribonucleotide containing the peptide residues with the alternated hydrophobic and basic amino acids was demonstrated.
[Active derivatives of oligonucleotides with a zwitterionic terminal phosphate group for design of affinity reagents and probes].
TLDR
Method of synthesis and isolation of oligonucleotide derivatives with a zwitterionic terminal phosphate group, containing N-methylimidazole (MeIm) or 4-dimethylaminopyridine 1-oxide (DMAPO) residues has been developed and is promising for synthesis of various oligon DNA phosphoramidates. Expand
Design and Targeted Reactions of Oligonucleotide Derivatives
TLDR
This book places antisense oligonucleotides in the context of drug discovery and development, reviewing the current status of research in antisense drugs and discussing strategies for future challenges and opportunities. Expand
Thermodynamic Analysis of Stacking Hybridization of Oligonucleotides with DNA Template
TLDR
Thermodynamic analysis reveals features of stacking oligonucleotide hybridization which allow one to predict the temperature dependence of association of oligon nucleotides and the DNA template within tandem complexes as well as to determine optimal concentration for formation of these complexes characterized by high co-operativity level. Expand
[Interaction of short oligonucleotides derivatives with nucleic acids. VI. Discrimination of mismatch-containing complexes upon ligation of a short oligonucleotide tandem on DNA template].
TLDR
The high ligation specificity of a tetranucleotide with a pair of flanking octanucleotides on DNA template by the action of T4 phage DNA ligase makes it possible to identify accurately any single nucleotide substitution in a tetanucleotide binding site. Expand
Nanoparticle-Mediated Nonviral DNA Delivery for Effective Inhibition of Influenza a Viruses in Cells
Development of new antiviral nucleic acid-based drugs and the search for their efficient delivery into cells are an urgent task. We prepared the TiO2·PL-DNA and TiO2·PL±DNA nanocomposites bearing DNAExpand
HYDROXYL RADICAL GENERATION BY OLIGONUCLEOTIDE DERIVATIVES OF ANTHRACYCLINE ANTIBIOTIC AND SYNTHETIC QUINONE
For the first time the covalent binding of anticancer anthracycline drugs and their potential synthetic analogs to oligonucleotides of different sequences is proposed for obtaining site-specific DNAExpand
Sequence-specific RNA cleavage by oligonucleotide-peptide conjugates
This paper considers the site-directed cleavage of the in vitro transcript of human tRNALys3 by the conjugate CNH2Gly(ArgLeu)3ArgLeuN—p-DAG—5"CCCTGGACCCTCAGAT3" (conjugate pep-1A) of theExpand
...
1
2
3
4
5
...