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The nature of the defect in tyrosine metabolism in alcaptonuria.
- B. La Du, V. Zannoni, L. Laster, J. Seegmiller
- Medicine, Biology
- The Journal of biological chemistry
Alcaptonuria is a rare, hereditary, metabolic disorder characterized by a defect in the oxidation of tyrosine (l-3). In this condition homogentisic acid, an intermediary product of tyrosine… Expand
Oxidation of homogentisic acid to ochronotic pigment in connective tissue.
- V. Zannoni, N. Lomtevas, S. Goldfinger
- Chemistry, Medicine
- Biochimica et biophysica acta
- 18 February 1969
Abstract Ochronotic pigmentation of connective tissues occurs in individuals with alcaptonuria. An enzyme system, termed homogentisic acid polyphenol oxidase, has been identified in mammalian skin… Expand
Studies on ochronosis. II. Studies on benzoquinoneacetic acid, a probale intermediate in the connective tissue pigmentation of alcaptonuria.
Benzoquinoneacetic acid, the quinone of homogentisic acid, given intraperitoneally to guinea pigs is distributed mainly into skin and cartilage, as found previously with homogentisic acid. In… Expand
A rapid micromethod for the determination of ascorbic acid in plasma and tissues.
Abstract A rapid simple micromethod for the determination of l -ascorbic acid in plasma and other biological tissues using orthophosphoric acid and ferric iron is presented. The ferric iron is… Expand
Hepatic microsomal epoxidation of bromobenzene to phenols and its toxicological implication.
318. In vitro microsomal hepatic epoxidation of bromobenzene in rats and mice is presented in this study. Formation of o-bromophenol via bromobenzene-2,3-epoxide and p-bromophenol via… Expand
DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene.
The role of various enzymes and biological molecules on the activation and deactivation of the metabolites of phenol was investigated in vitro. Phenol, the major metabolite of benzene, is metabolized… Expand
The role of ascorbic acid in drug metabolism.
EFFECTS OF ASCORBIC ACID ON MICROSOMAL DRUG METABOLISM *
Studies from a number of laboratories have shown that vitamin C deficiency in guinea pigs results in decreased metabolism of a variety of pharmacological agents.'-'" In 1941, Richards et al.' found a… Expand
Ascorbic acid and hepatic drug metabolism.
Previous in vivo studies indicate that hepatic microsomal drug metabolism decreases in ascorbic acid deficiency and is augmented when high supplements of the vitamin are given to guinea pigs. Kinetic… Expand
Inability of Methylprednisolone Sodium Succinate to Decrease Infarct Size or Preserve Enzyme Activity Measured 24 Hours after Coronary Occlusion in the Dog
Methylprednisolone sodium succinate (50 mg/kg) was given 30 minutes before or after the start of a 90 minute occlusion of the left circumflex coronary artery (LCX) in one group of dogs. In a second… Expand