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Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens
Individuals from different populations vary considerably in their susceptibility to immune-related diseases. To understand how genetic variation and natural selection contribute to these differences,Expand
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Phylogenetic and familial estimates of mitochondrial substitution rates: study of control region mutations in deep-rooting pedigrees.
We studied mutations in the mtDNA control region (CR) using deep-rooting French-Canadian pedigrees. In 508 maternal transmissions, we observed four substitutions (0.0079 per generation per 673 bp,Expand
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Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans
BackgroundThe 2’-5’ oligoadenylate synthetase (OAS) locus encodes for three OAS enzymes (OAS1-3) involved in innate immune response. This region harbors high amounts of Neandertal ancestry inExpand
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Genetic Structure of the Ancestral Population of Modern Humans
Abstract. Neutral DNA polymorphisms from an 8-kb segment of the dystrophin gene, previously ascertained in a worldwide sample (n= 250 chromosomes), were used to characterize the population ancestralExpand
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Ethiopia: between Sub-Saharan Africa and western Eurasia.
Ethiopia is central to population genetic studies investigating the out of Africa expansion of modern humans, as shown by Y chromosome and mtDNA studies. To address the level of geneticExpand
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Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
DNA methylation is an epigenetic mark thought to be robust to environmental perturbations on a short time scale. Here, we challenge that view by demonstrating that the infection of human dendriticExpand
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Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.
Although Africa has played a central role in human evolutionary history, certain studies have suggested that not all contemporary human genetic diversity is of recent African origin. We investigatedExpand
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Genetic heterogeneity in regional populations of Quebec--parental lineages in the Gaspe Peninsula.
Stable colonization of the Gaspe Peninsula by Europeans started in the middle of the 18th century at the time of the British conquest of New France. The earliest settlers were Acadians, escapingExpand
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Archaic lineages in the history of modern humans.
An important question in the ongoing debate on the origin of Homo sapiens is whether modern human populations issued from a single lineage or whether several, independently evolving lineagesExpand
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Nuclear DNA diversity in worldwide distributed human populations.
Nucleotide variation was examined in an 8 kb intronic DNA bordering exon 44 of the human dystrophin gene on Xp21. Thirty-six polymorphisms (substitutions, small insertions/deletions and one (T)nExpand
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