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DQAsome-mediated delivery of plasmid DNA toward mitochondria in living cells.
DQAsomes are mitochondriotropic cationic 'bola-lipid'-based vesicles, which have been developed by us for the transport of drugs and DNA to mitochondria in living cells. This has made directExpand
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DQAsomes: A Novel Potential Drug and Gene Delivery System Made from Dequalinium™
AbstractPurpose. Dequalinium, a drug known for over 30 years, is a dicationic amphiphile compound resembling bolaform electrolytes. The purpose of our work was to determine the state of aggregationExpand
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Xenogenic transfer of isolated murine mitochondria into human rho0 cells can improve respiratory function.
Mitochondrial DNA mutations are the direct cause of several physiological disorders and are also associated with the aging process. The modest progress made over the past two decades towardsExpand
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Nanopharmaceuticals (part 1): products on the market
In 2000, the National Institute of Health launched the National Nanotechnology Initiative to support, coordinate, and advance research and development of nanoscale projects. The impact of this newExpand
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Organelle-targeted nanocarriers: specific delivery of liposomal ceramide to mitochondria enhances its cytotoxicity in vitro and in vivo.
To further increase the therapeutic activity of drugs known to act on intracellular target sites, in vivo drug delivery approaches must actively mediate the specific delivery of drug molecules to theExpand
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DQAsome/DNA complexes release DNA upon contact with isolated mouse liver mitochondria.
DQAsomes are mitochondriotropic cationic vesicles, which have been developed by us for the supposed transport of DNA to mitochondria in living cells [Pharm. Res. 15 (1998) 334]. Our strategy for theExpand
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Liposomes and Liposome-like Vesicles for Drug and DNA Delivery to Mitochondria
Mitochondrial research is presently one of the fastest growing disciplines in biomedicine. Since the early 1990s, it has become increasingly evident that mitochondrial dysfunction contributes to aExpand
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Accumulation of Protein-Loaded Long-Circulating Micelles and Liposomes in Subcutaneous Lewis Lung Carcinoma in Mice
AbstractPurpose. The purpose of our work was to compare the biodistribution and tumor accumulation of a liposome- or micelle-incorporated protein in mice bearing subcutaneously-established Lewis lungExpand
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Mitochondrial leader sequence--plasmid DNA conjugates delivered into mammalian cells by DQAsomes co-localize with mitochondria.
In the last decade the increase in therapeutic strategies aimed at mitochondrial targets has resulted in the need for novel delivery systems for the selective delivery of drugs and DNA intoExpand
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Treatment Strategies that Enhance the Efficacy and Selectivity of Mitochondria-Targeted Anticancer Agents
Nearly a century has passed since Otto Warburg first observed high rates of aerobic glycolysis in a variety of tumor cell types and suggested that this phenomenon might be due to an impairedExpand
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