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Adenosine and inosine increase cutaneous vasopermeability by activating A(3) receptors on mast cells.
Adenosine has potent effects on both the cardiovascular and immune systems. Exposure of tissues to adenosine results in increased vascular permeability and extravasation of serum proteins. TheExpand
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  • Open Access
Computational approaches to fibril structure and formation.
Assembly of normally soluble proteins into amyloid fibrils is a cause or associated symptom of numerous human disorders. Although some progress toward understanding the molecular-level details ofExpand
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Genetic Factors Determine the Contribution of Leukotrienes to Acute Inflammatory Responses1
Leukotrienes (LT) are potent lipid mediators synthesized by the 5-lipoxygenase pathway of arachidonic acid (AA) metabolism. LT have been implicated in a broad spectrum of inflammatory processes. ToExpand
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Computer simulation study of amyloid fibril formation by palindromic sequences in prion peptides
We simulate the aggregation of large systems containing palindromic peptides from the Syrian hamster prion protein SHaPrP 113–120 (AGAAAAGA) and the mouse prion protein MoPrP 111–120 (VAGAAAAGAV) andExpand
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Fibrillization propensity for short designed hexapeptides predicted by computer simulation.
Assembly of normally soluble proteins into ordered aggregates, known as amyloid fibrils, is a cause or associated symptom of numerous human disorders, including Alzheimer's and the prion diseases.Expand
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Impact of sequence on the molecular assembly of short amyloid peptides
The goal of this work is to understand how the sequence of a protein affects the likelihood that it will form an amyloid fibril and the kinetics along the fibrillization pathway. The focus is on veryExpand
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