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Homology Modeling a Fast Tool for Drug Discovery: Current Perspectives
Major goal of structural biology involve formation of protein-ligand complexes; in which the protein molecules act energetically in the course of binding. Therefore, perceptive of protein-ligandExpand
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Therapeutic potential of snake venom in cancer therapy: current perspectives.
Many active secretions produced by animals have been employed in the development of new drugs to treat diseases such as hypertension and cancer. Snake venom toxins contributed significantly to theExpand
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Protective effect of Tephrosia purpurea in diabetic cataract through aldose reductase inhibitory activity.
PURPOSE Tephrosia purpurea (T. purpurea) has been reported to prevent cataract formation in senile cataract model as well as proven effective in STZ induced type 1 diabetes. Aldose reductase (AR) isExpand
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Synthesis, anti-inflammatory, analgesic, 5-lipoxygenase (5-LOX) inhibition activities, and molecular docking study of 7-substituted coumarin derivatives.
In the present study, 7-subsituted coumarin derivatives were synthesized using various aromatic and heterocyclic amines, and evaluated in vivo for anti-inflammatory and analgesic activity, and forExpand
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Pharmacophore modeling, virtual screening, docking and in silico ADMET analysis of protein kinase B (PKB β) inhibitors.
Protein kinase B (PKB) is a key mediator of proliferation and survival pathways that are critical for cancer growth. Therefore, inhibitors of PKB are useful agents for the treatment of cancer.Expand
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Virtual Screening: A Fast Tool for Drug Design
Computational screening of databases has become increasingly popular in the pharmaceutical research. Virtual screening uses computer based methods to discover new ligands on the basis of biologicalExpand
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Substituted benzimidazole derivatives as angiotensin II-AT1 receptor antagonist: a review.
  • V. Vyas, M. Ghate
  • Chemistry, Medicine
  • Mini reviews in medicinal chemistry
  • 30 November 2010
The renin angiotensin system (RAS) plays an important role in regulation of blood pressure and fluid-electrolyte homeostasis. The renin-angiotensin system consists of a cascade of enzymatic reactionsExpand
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Generation of new leads as HIV-1 integrase inhibitors: 3D QSAR, docking and molecular dynamics simulation
Human immunodeficiency virus type 1 integrase enzyme play a pivotal role (viral replication) in the Human immunodeficiency virus type 1 life cycle, and is recognized target for the development ofExpand
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Homology modeling, binding site identification and docking study of human angiotensin II type I (Ang II-AT1) receptor.
Ang II-AT1 receptors play an important role in mediating virtually all of the physiological actions of Ang II. Several drugs (SARTANs) are available, which can block the AT1 receptor effectively andExpand
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Insight into the Structural Requirement of 2-Alkyl-4-(biphenylmethoxy)quinolines as Nonpeptide Angiotensin II Receptor Antagonists: A QSAR Approach
In the current study a quantitative structure activity relationship approach using sequential multiple linear regression analysis was applied to a series of 2-alkyl- 4-(biphenylylmethoxy)quinolinesExpand
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