• Publications
  • Influence
Mammalian heparanase: what is the message?
  • V. Vreys, G. David
  • Medicine, Biology
  • Journal of cellular and molecular medicine
  • 1 May 2007
•  Heparan sulphate proteoglycans ‐  Heparan sulphate ‐  Heparan sulphate interactions ‐  Core proteins •  Heparanase ‐  Molecular properties of human heparanase‐1 ‐  Working mechanism and substrateExpand
  • 192
  • 15
JNJ-26481585, a Novel Second-Generation Oral Histone Deacetylase Inhibitor, Shows Broad-Spectrum Preclinical Antitumoral Activity
Purpose: Histone deacetylase (HDAC) inhibitors have shown promising clinical activity in the treatment of hematologic malignancies, but their activity in solid tumor indications has been limited.Expand
  • 128
  • 14
Cellular Uptake of Mammalian Heparanase Precursor Involves Low Density Lipoprotein Receptor-related Proteins, Mannose 6-Phosphate Receptors, and Heparan Sulfate Proteoglycans*
Mammalian heparanase, strongly implicated in the regulation of cell growth, migration, and differentiation, plays a crucial role in inflammation, angiogenesis, and metastasis. There is thus a clearExpand
  • 79
  • 2
The Novel Anticancer Agent JNJ-26854165 Induces Cell Death through Inhibition of Cholesterol Transport and Degradation of ABCA1
JNJ-26854165 (serdemetan) has previously been reported to inhibit the function of the E3 ligase human double minute 2, and we initially sought to characterize its activity in models of mantle cellExpand
  • 19
  • PDF
Abstract 5443: Rational combinations with the HDAC inhibitor JNJ-26481585: Prostate cancer and taxane therapy
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC We have recently reported the identification and characterization of JNJ-26481585, as a “second generation” oralExpand