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Glutamate regulation of calcium and IP3 oscillating and pulsating dynamics in astrocytes
TLDR
A concise mathematical model for glutamate-induced astrocytic intracellular Ca2 +  dynamics that captures the essential biochemical features of the regulatory pathway of inositol 1,4,5-trisphosphate (IP3) and the existence of new putative dynamical features is demonstrated. Expand
The Astrocyte as a Gatekeeper of Synaptic Information Transfer
TLDR
A simple biophysical model for the coupling between synaptic transmission and the local calcium concentration on an enveloping astrocytic domain is presented and suggests a novel, testable hypothesis for the spike timing statistics measured for rapidly firing cells in culture experiments. Expand
Nonlinear Gap Junctions Enable Long-Distance Propagation of Pulsating Calcium Waves in Astrocyte Networks
TLDR
A model of the gap-junctional route for intercellular Ca2+ wave propagation in astrocytes is proposed and it is shown that long-distance regenerative signaling requires nonlinear coupling in the gap junctions, and short-distance Regenerative signaling is favored when the internalCa2+ dynamics implements frequency modulation-encoding oscillations with pulsating dynamics. Expand
Downregulation of Parvalbumin at Cortical GABA Synapses Reduces Network Gamma Oscillatory Activity
TLDR
A biophysically realistic and detailed computational model of a cortical circuit including asynchronous release from GABAergic interneurons is developed to investigate how reductions in PV and GABA affect gamma oscillations induced by sensory stimuli, and suggests a mechanism by which reduced GAD67 and PV in fast-spiking interneeurons may contribute to cortical dysfunction in schizophrenia and related psychiatric disorders. Expand
Computational quest for understanding the role of astrocyte signaling in synaptic transmission and plasticity
TLDR
The possibility that astrocytes perform genuine information processing by means of their calcium signaling and are players in the physiological setting of the basal tone of synaptic transmission is considered, supported by experimental evidence. Expand
A Tale of Two Stories: Astrocyte Regulation of Synaptic Depression and Facilitation
TLDR
This model explains several experimental observations yet unsolved, and uncovers astrocytic gliotransmission as a possible transient switch between short-term paired-pulse depression and facilitation, which has deep implications on the processing of neuronal spikes and resulting information transfer at synapses. Expand
The emergence and properties of mutual synchronization in in vitro coupled cortical networks
TLDR
The results agree with the experimental findings that the initiation and function asymmetry can be separately regulated, which implies that information transfer (activity propagation) and information processing (function) can be regulated separately in coupled neural networks. Expand
Coexistence of amplitude and frequency modulations in intracellular calcium dynamics.
TLDR
The encoding of these external signals in the context of the Li-Rinzel model is studied and it is shown that by control of biophysical parameters the information can be encoded in amplitude modulation (AM), frequency modulation (FM), or mixed (AM and FM) modulation. Expand
Multimodal encoding in a simplified model of intracellular calcium signaling
TLDR
The minimal model of Li and Rinzel is considered and it is shown that information encoding can occur by AM of Ca2+ oscillations, by FM or by both modes (AFM), which can be crucial for a better understanding of synaptic information transfer. Expand
Pattern of trauma determines the threshold for epileptic activity in a model of cortical deafferentation
TLDR
This work analyzed the dynamics of a large-scale biophysically realistic cortical network model subjected to different patterns of trauma to suggest that the spatial pattern of trauma can greatly affect the propensity for developing posttraumatic epileptic activity. Expand
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